The Westerfield Lab
Contact Info:
Phone: (541) 346-4596
Fax: (541) 346-4548
Contact Person: Judy Peirce
Email: judyp@uoneuro.uoregon.edu
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| Lab Members: |
Bernardo Blanco, Research Associate
Devin Clark, Student
Tom Dudrey, Student
Richard Edmunds, Research Associate
Braden Larson, Student
Judy Peirce, Research Assistant
Jennifer
Phillips, Research Associate |
Alexandra Tallafuss, Research Associate
Sabrina Toro, Research Associate
Stephanie van der Weide, Student
Jeremy
Wegner, Research Assistant
Monte
Westerfield, Professor
Alex Westlake, Student
Westerfield Lab Alumni |
| ZFIN Database: |
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Leyla
Bayraktaroglu, Scientific Curator
Yvonne Bradford, Scientific Curator
Tom
Conlin, Scientific Curator
Nathan Dunn, Software Engineer
David
Fashena, Scientific Curator
Ken
Frazer, Scientific Curator
Doug
Howe, Scientific Curator
Jonathan Knight, Adminstrative Assistant
Prita
Mani, Software Engineer
Christian Pich, Software Engineer
Sridhar
Ramachandran, Scientific Curator |
Barbara Ruef, Scientific Curator
Kevin
Schaper, Software Engineer
Holle Schaper, Adminstrative Assistant
Xiang Shao, Software Engineer
Amy Singer, Scientific Curator
Judy
Sprague , Director
Brock
Sprunger, Software Engineer
Peiran
Song, Database Administrator
Sierra
Moxon, Database Administrator
Ceri
Van Slyke, Scientific Curator
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| Zebrafish
International Resource Center: |
Austin
Bailey, Research Assistant
Carrie Barton, Research Assistant
Justin Bauer, Research Assistant
Carrie
Carmichael, Research Assistant
Renee Clark, Research Assistant
April
Freeman, Research Assistant
Terra Hiebert, Research Assistant
Ron
Holland, Database Administrator
Jen-Jen Hwang-Shum, Research Associate |
Michael
Kent, Professor
David
Lains , Research Assistant
Katy Murray, Veterinarian
Andrzej Nasiadka, Research Associate
Erin
Quinn, Administrative Assistant
Calvin Smith, Research Assistant
Evan Williams, Research Assistant
Zoltan
Varga, Director |
Research Interests:
Our laboratory focuses on understanding the mechanisms that regulate the differentiation of neurons. We study how the specific properties of different kinds of neurons are regulated.
We use zebrafish and a combination of anatomical, physiological, molecular, and genetic techniques. The goal of our research is to provide a better understanding of the mechanisms that regulate the establishment of specific neuronal cell fates during normal development and what goes wrong during disease.
Current projects include understanding the molecular genetics of ear and eye and development, especially as models of human disease. In particular, we are making and studying models of human Usher syndrome, the leading cause of deafblindness.
Lab Haikus from annual Institute retreat:
Mutant hunt is fun
Tangoing through the gene pool
Don't drink the water |
Free the zebrafish!
Take them to Amazon Creek
We need more field trips |
Some Recent Publications:
- Washington, N.L., M.A. Haendel, C.J. Mungall, M. Ashburner, M. Westerfield, and S.E. Lewis. (2009). Linking human diseases to animal models using ontology-based phenotype annotation. PLoS Bio. 7, e1000247.
- Ochi, H., and M. Westerfield. (2009). Lbx2 regulates formation of myofibrils. BMC Dev. Bio. 9, 13.
- Rotllant, J., D. Liu, Y.-L. Yan, J.H. Postlethwait, M. Westerfield, and S.-J. Du. (2008). Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix Biol. 27, 561-572.
- Dutta, S., J.-E. Dietrich, M. Westerfield, and Z.M. Varga. (2008). Notch signaling regulates endocrine cell specification in the zebrafish anterior pituitary. Dev. Biol. 319, 248-57.
Ochi, H., S. Hans and M. Westerfield. (2008). Smarcd3 regulates the timing of zebrafish myogenesis onset. J. Biol. Chem. 283, 3529-2526.
Nixon, S.J., A. Carter, J. Wegner, C. Ferguson, M. Floetenmeyer, J. Riches, B. Key, M. Westerfield, and R.G. Parton. (2007). Caveolin-1 is required for lateral line neuromast and notochord development. J. Cell Sci. 120, 2151-61.
Hans, S., J. Christison, D. Liu and M. Westerfield. (2007). Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC Dev. Biol. 7: 5.
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Ochi, H. and M. Westerfield. (2007). Signaling networks that regulate muscle development: lessons from zebrafish. Dev. Growth Diff. 49:1-11.
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Hans, S. and M. Westerfield. (2007). Changes in retinoic acid signaling alter otic patterning. Development 134, 2449-2458.
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Mabee, P.M.,G. Arratia, M. Coburn, M. Haendel, E.J. Hilton, J.G. Lundberg, R.L. Mayden, N. Rios, and M. Westerfield. (2007). Connecting evolutionary morphology to genomics using ontologies: A case study from Cypriniformes including zebrafish. J. Exp. Zool. B Mol. Dev. Evo. 308B, 655-668.
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Chen, Y.-H., Y.-H. Wang, M.-Y. Chang, C.-Y.Lin, C.-W. Weng, M. Westerfield, H.-J. Tsai. (2007). Multiple upstream modules regulate zebrafish myf5expression. BMC Dev. Biol. 7, 1.
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Peng, G and M. Westerfield. (2006). Lhx5 Promotes Forebrain Development by Regulating Secreted Wnt Antagonists. Development 133, 3191-3200.
- Ochi, H., B.J. Pearson, P.-T. Chuang, M. Hammerschmidt and M. Westerfield. (2006). Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating internalization of Smoothened. Developmental Biol. 297, 127-40.
- Nixon, J. Wegner, C. Ferguson, P.-F. Méry, J.F. Hancock, P.D. Currie, B. Key, M. Westerfield, and R.G. Parton. (2005). Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterning. Hum. Mol. Genet. 14, 1727-1743.
- Dutta S., J.-E. Dietrich, G. Aspöck, R.D. Burdine, A. Schier, M. Westerfield and Z.M. Varga. (2005). pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development 132, 159-190.
- Hans, S., D. Liu and M. Westerfield. (2004) Pax8
and Pax2a function synergistically in otic specification,
downstream of the Foxi1 and Dlx3b transcription
factors. Development 131, 5091-5102.
- Hirsinger, E., F. Stellabotte, S.H. Devoto,
and M. Westerfield. (2004). Hedgehog is required
for commitment but not initial induction of slow
muscle precursors. Dev. Biol. 275, 143-157.
- Jensen, A.M. and
M. Westerfield. (2004). Zebrafish Mosaic eyes
is a novel FERM protein required for retinal
lamination and retinal pigmented epithelial tight
junction formation.
Curr. Biol. 14, 711-717.
List of all publications.
Links:
ZFIN (the zebrafish
information network)
- the zebrafish model organism database.
The Zebrafish Database
Project - status of ZFIN, the on-line database of zebrafish information.
The
Zebrafish International Resource Center -
resource and stock center for zebrafish.
The Society for Developmental Biology
Association for Research in Vision and Opthalmology
The Society for Neuroscience
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