The Westerfield Laboratory
Contact Info:
Phone: (541) 346-4596
Fax: (541) 346-4548
Contact Person: Judy Peirce
Email: judyp@uoneuro.uoregon.edu |
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| Lab Members: |
Bernardo Blanco, Research Associate
Jessica Cheung, Student
Aurélie Clément, Research Associate
Haley Engle, Student
Judy Peirce, Research Assistant
Jennifer
Phillips, Research Associate
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Marcel Rockwell, Student
Sabrina Toro, Research Associate
Nicole Villegas, Student
Jeremy
Wegner, Research Assistant
Monte
Westerfield, Professor
Westerfield Lab Alumni |
| ZFIN Database: |
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Leyla
Bayraktaroglu, Scientific Curator
Yvonne Bradford, Scientific Curator
Tom
Conlin, Scientific Curator
Nathan Dunn, Software Engineer
David
Fashena, Scientific Curator
Ken
Frazer, Scientific Curator
Doug
Howe, Scientific Curator
Jonathan Knight, Adminstrative Assistant
Prita
Mani, Software Engineer
Christian Pich, Software Engineer
Sridhar
Ramachandran, Scientific Curator |
Barbara Ruef, Scientific Curator
Kevin
Schaper, Software Engineer
Holle Schaper, Adminstrative Assistant
Xiang Shao, Software Engineer
Amy Singer, Scientific Curator
Judy
Sprague , Director
Brock
Sprunger, Software Engineer
Peiran
Song, Database Administrator
Sierra
Moxon, Database Administrator
Ceri
Van Slyke, Scientific Curator
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| Zebrafish
International Resource Center: |
Justin Bauer, Fish Facility Staff
Irina Botvinnik, Technical Staff
Carrie
Carmichael, Research Assistant
Renee Clark, Fish Facility Staff
April
Freeman, Administrative Staff
Gordon Hennesey, Technical Staff
Ron
Holland, Database Administrator
Jen-Jen Hwang-Shum, Research Associate
Michael
Kent, Professor |
Evan Loucks, Fish Facility Staff
David
Lains , Fish Facility Staff
Bruce McCarthy, Techincal Staff
Katy Murray, Veterinarian
Andrzej Nasiadka, Research Associate
Erin
Quinn, Administrative Assistant
Calvin Smith, Fish Facility Staff
Evan Williams, Fish Facility Staff
Zoltan
Varga, Director |
Research Interests:
Our laboratory focuses on understanding the mechanisms that regulate the differentiation of neurons. We study how the specific properties of different kinds of neurons are regulated.
We use zebrafish and a combination of anatomical, physiological, molecular, and genetic techniques. The goal of our research is to provide a better understanding of the mechanisms that regulate the establishment of specific neuronal cell fates during normal development and what goes wrong during disease.
Current projects include understanding the molecular genetics of ear and eye and development, especially as models of human disease. In particular, we are making and studying models of human Usher syndrome, the leading cause of deafblindness.
Lab Haikus from annual Institute retreat:
Mutant hunt is fun
Tangoing through the gene pool
Don't drink the water |
Free the zebrafish!
Take them to Amazon Creek
We need more field trips |
Some Recent Publications:
- Phillips, J.B., Blanco-Sanchez, B., Lentz, J.L., Tallafuss, A., Khanobdee, K., Sampath, S., Jacobs, Z.G., Han, P.F., Mishra, M., Williams, D.S., Keats, B.J., Washbourne, P., and Westerfield, M. 2011. Harmonin (Ush1c) is required in zebrafish Muller glial cells for photoreceptor synaptic development and function. Dis. Mod. Mech. 4, 786-800.
- Ebermann, I., Phillips, J. B., Liebau, M. C., Koenekoop, R. K., Schermer, B., Lopez, I., Schafer, E., Roux, A. F., Dafinger, C., Bernd, A., et al.. (2010). PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome. J Clin Invest 120, 1812-23.
- Dahdul W.M., J.P. Balhoff, J. Engeman, T. Grande, E.J. Hilton, C. Kothari, H. Lapp, J.G. Lundberg, P.E. Midford, T.J. Vision, M. Westerfield, and P.M. Mabee. (2010). Evolutionary Characters, Phenotypes and Ontologies: Curating Data from the Systematic Biology Literature. PLoS ONE 5, e10708.
- Balhoff J.P., W.M. Dahdul, C.R. Kothari, H. Lapp, J.G. Lundberg, P. Mabee, P.E. Midford, M. Westerfield, and T.J. Vision. (2010). Phenex: Ontological annotation of phenotypic diversity. PLoS ONE 5, e10500.
- Dahdul, W.M., J.G. Lundberg, P.E. Midford, J.P. Balhoff, H. Lapp, T.J. Vision, M.A. Haendel, M. Westerfield, and P.M. Mabee. (2010). The Teleost Anatomy Ontology: Anatomical representation for the genomics age. Systematic Bio. 59, 1-15.
- Viktorin, G., C. Chiuchitu, M. Rissler, Z.M. Varga, and M. Westerfield. (2009). Emx3 is required for the differentiation of dorsal telencephalic neurons. Dev. Dyn. 238,1984-98.
- Washington, N.L., M.A. Haendel, C.J. Mungall, M. Ashburner, M. Westerfield, and S.E. Lewis. (2009). Linking human diseases to animal models using ontology-based phenotype annotation. PLoS Bio. 7, e1000247.
- Rotllant, J., D. Liu, Y.-L. Yan, J.H. Postlethwait, M. Westerfield, and S.-J. Du. (2008). Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix Biol. 27, 561-572.
- Dutta, S., J.-E. Dietrich, M. Westerfield, and Z.M. Varga. (2008). Notch signaling regulates endocrine cell specification in the zebrafish anterior pituitary. Dev. Biol. 319, 248-57.
- Nixon, S.J., A. Carter, J. Wegner, C. Ferguson, M. Floetenmeyer, J. Riches, B. Key, M. Westerfield, and R.G. Parton. (2007). Caveolin-1 is required for lateral line neuromast and notochord development. J. Cell Sci. 120, 2151-61.
Hans, S., J. Christison, D. Liu and M. Westerfield. (2007). Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC Dev. Biol. 7: 5.
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Hans, S. and M. Westerfield. (2007). Changes in retinoic acid signaling alter otic patterning. Development 134, 2449-2458.
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Mabee, P.M.,G. Arratia, M. Coburn, M. Haendel, E.J. Hilton, J.G. Lundberg, R.L. Mayden, N. Rios, and M. Westerfield. (2007). Connecting evolutionary morphology to genomics using ontologies: A case study from Cypriniformes including zebrafish. J. Exp. Zool. B Mol. Dev. Evo. 308B, 655-668.
List of all publications.
 Links:
ZFIN (the zebrafish
information network)
- the zebrafish model organism database.
The
Zebrafish International Resource Center -
resource and stock center for zebrafish.
The Society for Developmental Biology
Association for Research in Vision and Opthalmology
The Society for Neuroscience
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