The Westerfield Lab
Contact Info:
Phone: (541) 346-4596
Fax: (541) 346-4548
Contact Person: Judy Peirce
Email: judyp@uoneuro.uoregon.edu
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| Lab Members: |
Gudrun Aspöck, Research Associate
Jennifer Chiem, Student
Joe
Christison, Student
Dam Lam, Student
Braden Larson, Student
Dong Liu,
Research Associate
Haruki
Ochi, Research Associate
Sarah Namugenyi, Student
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Judy Peirce, Research Assistant
Gang
Peng, Research Associate
Jennifer
Phillips, Research Associate
Sabrina Toro, Research Associate
Jeremy
Wegner, Research Assistant
Monte
Westerfield, Professor
Alex Westlake, Student
Westerfield Lab Alumni |
| ZFIN Database: |
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Leyla
Bayraktaroglu, Scientific Curator
Yvonne Bradford, Scientific Curator
Tom
Conlin, Scientific Curator
David
Fashena, Scientific Curator
Ken
Frazer, Scientific Curator
Sherry
Giglia, Communication Coordinator
Melissa
Haendel, Scientific Curator
Doug
Howe, Scientific Curator
Jonathan Knight, Adminstrative Assistant
Prita
Mani, Software Engineer
Christian Pich, Software Engineer |
Sridhar
Ramachandran, Scientific Curator
Kevin
Schaper, Software Engineer
Xiang Shao, Software Engineer
Amy Singer, Scientific Curator
Judy
Sprague , Director
Brock
Sprunger, Software Engineer
Peiran
Song, Database Administrator
Sierra
Moxon, Database Administrator
Ceri
Van Slyke, Scientific Curator
Marie Susana Valle, Adminstrative Assistant |
| Zebrafish
International Resource Center: |
Austin
Bailey, Research Assistant
Kostia Birulin , Research Assistant
Carrie
Carmichael, Research Assistant
Carrie Cleeton, Research Assistant
Renee Clark, Research Assistant
April
Freeman, Research Assistant
Terra Hiebert, Research Assistant
Ron
Holland, Database Administrator
Jen-Jen Hwang-Shum, Reearch Associate
Michael
Kent, Professor |
David
Lains , Research Assistant
Tim
Mason, Programmer
Katy Murray, Veterinarian
Beth Murrill, Research Assistant
Andrzej Nasiadka, Research Associate
Erin
Quinn, Administrator
Jennifer Ramsay, Student
Evan Williams, Research Assistant
Zoltan
Varga, Director |
Research Interests:
Our laboratory focuses on understanding the mechanisms that regulate the differentiation of neurons. We study how the specific properties of different kinds of neurons are regulated.
We use zebrafish and a combination of anatomical, physiological, molecular, and genetic techniques. The goal of our research is to provide a better understanding of the mechanisms that regulate the establishment of specific neuronal cell fates during normal development and what goes wrong during disease.
Current projects include understanding the molecular genetics of ear, eye and muscle development, particularly as models of human disease. In particular, we are making and studying models of human Usher syndrome, the leading cause of deafblindness.
Lab Haiku from annual Institute retreat:
Mutant hunt is fun
Tangoing through the gene pool
Don't drink the water
Some Recent Publications:
- Ochi, H., S. Hans and M. Westerfield. (2008). Smarcd3 regulates the timing of zebrafish myogenesis onset. J. Biol. Chem. 283, 3529-2526.
- Nixon, S.J., A. Carter, J. Wegner, C. Ferguson, M. Floetenmeyer, J. Riches, B. Key, M. Westerfield, and R.G. Parton. (2007). Caveolin-1 is required for lateral line neuromast and notochord development. J. Cell Sci. 120, 2151-61.
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Hans, S., J. Christison, D. Liu and M. Westerfield. (2007). Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC Dev. Biol. 7: 5.
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Ochi, H. and M. Westerfield. (2007). Signaling networks that regulate muscle development: lessons from zebrafish. Dev. Growth Diff. 49:1-11.
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Hans, S. and M. Westerfield. (2007). Changes in retinoic acid signaling alter otic patterning. Development 134, 2449-2458.
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Mabee, P.M.,G. Arratia, M. Coburn, M. Haendel, E.J. Hilton, J.G. Lundberg, R.L. Mayden, N. Rios, and M. Westerfield. (2007). Connecting evolutionary morphology to genomics using ontologies: A case study from Cypriniformes including zebrafish. J. Exp. Zool. B Mol. Dev. Evo. 308B, 655-668.
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Chen, Y.-H., Y.-H. Wang, M.-Y. Chang, C.-Y.Lin, C.-W. Weng, M. Westerfield, H.-J. Tsai. (2007). Multiple upstream modules regulate zebrafish myf5expression. BMC Dev. Biol. 7, 1.
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Peng, G and M. Westerfield. (2006). Lhx5 Promotes Forebrain Development by Regulating Secreted Wnt Antagonists. Development 133, 3191-3200.
- Ochi, H., B.J. Pearson, P.-T. Chuang, M. Hammerschmidt and M. Westerfield. (2006). Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating internalization of Smoothened. Developmental Biol. 297, 127-40.
- Nixon, J. Wegner, C. Ferguson, P.-F. Méry, J.F. Hancock, P.D. Currie, B. Key, M. Westerfield, and R.G. Parton. (2005). Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterning. Hum. Mol. Genet. 14, 1727-1743.
- Dutta S., J.-E. Dietrich, G. Aspöck, R.D. Burdine, A. Schier, M. Westerfield and Z.M. Varga. (2005). pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development 132, 159-190.
- Hans, S., D. Liu and M. Westerfield. (2004) Pax8
and Pax2a function synergistically in otic specification,
downstream of the Foxi1 and Dlx3b transcription
factors. Development 131, 5091-5102.
- Hirsinger, E., F. Stellabotte, S.H. Devoto,
and M. Westerfield. (2004). Hedgehog is required
for commitment but not initial induction of slow
muscle precursors. Dev. Biol. 275, 143-157.
- Jensen, A.M. and
M. Westerfield. (2004). Zebrafish Mosaic eyes
is a novel FERM protein required for retinal
lamination and retinal pigmented epithelial tight
junction formation.
Curr. Biol. 14, 711-717.
List of all publications.
 Links:
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