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Projects |
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Synaptogenesis in zebrafish: We are using the touch response assay, immunostaining and live imaging to dissect mechanisms involved in forming functional synapses in the embryonic zebrafish spinal cord. We are currently concentrating on the cell adhesion molecules Neuroligin and SynCAM and on the function of NMDA receptors in gaining functionality of synapses. |
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Downstream signaling of cell adhesion molecules: We are using neuronal cultures from rat and mouse cortex to determine the methods by which the cell adhesion molecules signal to the intracellular milieu to bring about recruitment of pre- and postsynaptic molecules. We are also generating transgenic mice to determine the function of the adhesion molecules In vivo. |