CURRICULUM VITAE

Name: John H. Postlethwait

Position: Professor of Biology

Present Address: Institute of Neuroscience

1254 University of Oregon

Eugene, Oregon 97403-1254

Office (541) 346-4538 / Fax (541) 346-4548

E-mail: jpostle@uoneuro.uoregon.edu

Education:

Purdue University B.A. 1966 Biology

University of California, Irvine Predoc 1968-70 Developmental Genetics

Case Western Reserve University Ph.D. 1970 Developmental Genetics

Harvard University Postdoc 1970-71 Molecular Genetics

Research and Professional Experience:

1971-1977 Assistant Professor of Biology, University of Oregon

1977-1981 Associate Professor of Biology, University of Oregon

1977-1978 Visiting Research Scientist, Institute for Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria

1982-1983 Visiting Research Scientist, CNRS, Laboratory of Eukaryotic Molecular Genetics, Strasbourg, France

1989-1990 Visiting Research Scientist, Imperial Cancer Research Fund, Oxford University, Oxford, Great Britain

1981-present Professor of Biology, University of Oregon

1987-present Affiliate, Institute of Molecular Biology, University of Oregon

1990-present Member, Institute of Neuroscience, University of Oregon

Awards and Honors:

1966 Phi Beta Kappa, Purdue University

1974-1979 Research Career Development Award, National Institutes of Health

1979 Recipient, Ersted Distinguished Teaching Award, University of Oregon

1988 Fellow of the American Association for the Advancement of Science

1997 Recipient, Kezer Distinguished Teacher Award, Biology Department, University of Oregon

2000 Distinguished Alumnus Award, Purdue University

2001 Distinguished Alumnus Award, Jefferson High School, Lafayette, Indiana

2007 Medical Research Foundation Discovery Award

2007 Oregon Discovers Achievement Award

2009 Humbolt Research Award, Germany

Professional Service (2003-present):

2000-2006 Director, NSF IGERT training grant on Evolution, Development and Genomics

2003-2005 NIH Comparative Medicine Study Section Regular Panel Member

2003-2006 Editorial Board, Molecular and Developmental Evolution

2004-2006 Genetics Society of America, Advisory Board Member

2004-2007 NSF-NIEHS Oceans and Human Health External Advisory Panel member

2005 NIH Special Emphasis Panel

2005-2006 NSF Animal Development Panel

2006 Special Emphasis Panel/Scientific Review Group 2006/05 GNOM-G (M1)

Publications (194 total)

Journal Articles Published

2009

Jovelin, R, Yan, Y-L, He, X., Catchen, J, Amores, A, Canestro, C, Yokoi, H, Postlethwait, JH (2009) Evolution of developmental regulation in the vertebrate FgfD subfamily. JEZ Part B: Molecular and Developmental Evolution. In press. PMC Journal: pending.

Catchen, JM, Conery, JS, Postlethwait, JH (2009) Automated identification of conserved synteny after whole genome duplication, Genome Research, 19(8):1497-505.  PMC2720179

Cañestro, C, Catchen, JM, Rodríguez-Marí, A, Yokoi, H, Postlethwait, JH (2009) Consequences of Lineage-specific Gene Loss on Functional Evolution of Surviving Paralogs: ALDH1A and Retinoic Acid Signaling in Vertebrate Genomes. PLoS Genet. 5(5):e1000496. PMC2682703.

Titus, T., Yan, Y.-L., Wilson, C., Starks, A., Frohnmayer, J., Canestro, C., Rodriguez-Mari, A., He, X., Postlethwait, J.H. (2009) The Fanconi anemia/BRCA gene network in zebrafish: Embryonic expression and comparative genomics. Mutat Res. 668(1-2):117-32. PMC2714409

Albertson, R.C., Cresko, W., Detrich, III, H.W., Postlethwait, J.H. (2009) Evolutionary Mutant Models for Human Disease. Trends in Genetics, 25(2):74-81. PMC Journal: pending

Yokoi, H., Yan, Y.-L., Miller, M.R., BreMiller, RA., Catchen, J.M., Johnson. E., and Postlethwait, J.H. (2009) Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation. Developmental Biology 329:1–15. PMC2706370.

He, X., Eberhart, J.K., Postlethwait, J.H. (2009) MicroRNAs and micromanaging the skeleton in disease, development, and evolution. J Cell Mol Med. 13(4):606-18. PMC: pending.

2008

Nakamura, Y., He, X., Kobayashi, T., Yan, Y.-L., Postlethwait, J.H., Warman, M.L. (2008) Unique roles of microRNA140 and its host gene WWP2 in cartilage biology. J Musculoskelet Neuronal Interact. 8(4):321-2. PMC: pending.

Rotllant, J., Liu, D., Yan, Y.-L., Postlethwait, J. H., Westerfield, M., Du, S.-J. (2008) Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix Biology 27, 561-72. PMCID: PMC2642737.

Cañestro, C., Bassham, S., and Postlethwait, J. H. (2008) Evolution of the thyroid: anterior-posterior regionalization of the Oikopleura endostyle revealed by Otx, Pax2/5/8, and Hox1 expression. Developmental Dynamics 237, 1490-9. PMC Journal: pending

Eberhart, J. K., He, X., Swartz, M. E., Yan, Y.-L., Song, H., Boling, T. C., Kunerth, A. K., Walker, M. B., Kimmel, C. B., and Postlethwait, J. H. (2008) MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nature Genetics 40, 290-8.

Lewis, Z.R., McClellan, M.C., Postlethwait, J.H., Cresko, W., Kaplan, R. (2008) Female-specific increase in primordial germ cells marks sex differentiation in threespine stickleback (Gasterosteus aculeatus). J. Morphol. 269, 909-21.

Bassham, S., Cañestro, C., and Postlethwait, J.H. (2008) Evolution of developmental roles of Pax2/5/8 paralogs after independent duplication in urochordate and vertebrate lineages. BMC Biol. 2008; 6: 35. PMCID: PMC2532684

2007

Miller, M. R., Atwood, T. S., Eames, B. F., Eberhart, J. K., Yan, Y.-L., Postlethwait, J. H. and Johnson, E. A. (2007) RAD marker microarrays enable rapid mapping of zebrafish mutations. Genome Biology 8(6): R105. PMCID: PMC2394753.

Cresko, W. A., McGuigan, K. L., Phillips, P. C. and Postlethwait, J. H. (2007) Studies of threespine stickleback developmental evolution: progress and promise. Genetica 129,105-26.

Cañestro, C., Yokoi, H., and John H. Postlethwait (2007) Evolutionary developmental biology and genomics. Nature Review Genetics 12, 932-42.

Jovelin, R., He, X., Amores, A., Yan, Y.-L., Shi, R., Qin, B., Roe, B., Cresko, W. A., and Postlethwait, J. H. (2007) Duplication and divergence of fgf8 functions in teleost development and evolution. J. Exper. Zool. (Mol. Dev. Evol.) 308B, 1-14.

Miller, M. R., Eames. B. F., Eberhart, J. K., Yan, Y.-L., Postlethwait, J. H. and Johnson, E. A. (2007) RAD marker microarrays enable rapid mapping of zebrafish mutations. Gen. Biol. 8, R105.

Catchen, J. M., Conery, J. S., and Postlethwait, J. H. (2007) Inferring Ancestral Gene Order. In: Methods in Molecular Biology: Bioinformatics 452, 365-83. Editor: Jonathan Keith. Humana Press, Totowa, New Jersey.

Cañestro, D. and Postlethwait, J. H. (2007) Development of a chordate anterior-posterior axis without classical retinoic acid signaling. Dev. Biol. 15, 522-38.

Sakata, S.I., Yan, Y., Satou, Y., Momoi, A., Ngo-Hazelett, P., Nozaki, M., Furutani-Seiki, M., Postlethwait, J. H., Yonehara, S., and Sakamaki, K. (2007) Conserved function of caspase-8 in apoptosis during bony fish evolution. Gene 396, 134-48.

Sullivan, C., Lage, C., Millard, P., Postlethwait, J. H., and Kim, C. H. (2007). Evidence for evolving TICAM function in vertebrates. Journal of Immunology 178, 4517-27.

2006

Postlethwait, J. H. (2006) The zebrafish genome in context: Ohnologs gone missing. J. Exp. Zool. (Mol. Dev. Evol.) 306B, [page range TBA].

Nolte, C., Rastegar, M., Amores, A., Bouchard, M., Grote, D., Maas, R., Kovacs, E., Postlethwait, J., Rambaldi, I., Rowan, S., Yan, Y.L., Zhang, F., and Featherstone, M. (2006) Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis. Developmental Biology 299, 582-593.

Postlethwait, J. H. (2006) The zebrafish genome: A review and case study of msx genes. Genome Dynamics 2, 183-197.

Leveille, F., Ferrer, M., Medhurst, A. L., Laghmani, E. H., Rooimans, M. A., Bier, P. Steltenpool, J., Titus, T. A., Postlethwait, J. H., Hoatlin, M. E., Joenje, H., and de Winter, J. P. (2006) The nuclear accumulation of the Fanconi anemia protein FANCE depends on FANCC. DNA Repair 5, 556-565.

Titus, T. A., Selvig, D. R., Quin, B., Wilson, I., Starks. A., Roe, B. A. and J. H. Postlethwait (2006) The Fanconi anemia gene network is conserved from zebrafish to human. Gene 371, 211-223.

Bromee T., Venkatesh, B., Brenner, S., Postlethwait, J.H., Yan, Y.-L., and Larhammar, D. (2006) Uneven evolutionary rates of bradykinin B1 and B2 receptors in vertebrate lineages. Gene 373,100-108.

Cañestro, C., Postlethwait, J. H., Gonzalez-Duarte, R. and Albalat, R. (2006) Is retinoic acid genetic machinery a chordate innovation? Evol. Development 8, 394-406.

Phillips, R. B., Amores, A., Morasch, M. R., Wilson, C., and Postlethwait, J. H. (2006) Assignment of zebrafish genetic linkage groups to chromosomes. Cyto. Genome Res. 114, 155-62.

Tallafuss, A., Hale, L. A., Yan, Y. L., Dudley, L., Eisen, J. S., and Postlethwait, J. H. (2006) Characterization of retinoid-X receptor genes rxra, rxrba, rcrbb and rxrg during zebrafish development. Gene Expr. Patterns 6, 556-565.

Hale, L. A., Tallafuss, A., Yan, Y. L., Dudley, L., Eisen, J. S., and Postlethwait, J. H. (2006) Characterization of the retinoic acid receptor genes raraa, rarab and rarg during zebrafish development. Gene Expr. Patterns 6, 546-555.

2005

Bassham, S. and Postlethwait, J. (2005) The evolutionary history of placodes: a molecular genetic investigation of the larvacean urochordate Oikopleura dioica. Development 132, 4259-72.

Woods, I. G., Wilson, C., Friedlander, B., Chang, P., Reyes, D. K., Nix, R., Kelly, R. D., Chu, F., Postlethwait, J. H., and Talbot, W. S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome Research 15, 1307-1314.

Canestro, C., Bassham, S., and Postlethwait, J. H. (2005) Development of the central nervous system in the larvacean Oikopleura dioica and the evolution of the chordate brain. Devel. Bio. 285, 298-315.

Kuo, M-W., Lou, S-W. Postlethwait, J. H., and Chung, B-C. (2005) Chromosomal organization, evolutionary relationship, and expression of zebrafish GnRH family members. J. Biomed. Sci. 389, 19-26.

Albertson, R. C., Payne-Ferreira, T. L., Postlethwait, J., and P. C. Yelick (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Dev. Dyn. 233, 1405-18.

Kimmel, C., Ullmann, B., Walker, C., Wilson, C., Currey, M., Phillips, P., Bell, M. A., Postlethwait, J. H., and Cresko, W. (2005) Evolution and development of facial bone morphology in threespine stickleback. PNAS 102, 5791-6.

Lagerstrom, M., Fredriksson, R., Bjarnadottier, T., Fridmanis, D., Holmquist, T., Andersson, J., Yan, Y., Raudsepp, T., Zoorob, R., Kukkonen, J. P., Lundin, L., Klovins, J., Chowdhary, B., and Postlethwait, J. (2005) Origin of the prolactin-releasing hormone (PRLH) receptors: Evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. Genomics 85, 688-703.

Tanaka, M., Hale, L., Amores, A., Yan, Y., Cresko, W., Suzuki, T., and Postlethwait, J. (2005) Developmental genetic basis for the evolution of pelvic fin loss in the pufferfish Takifugu rubripes. Dev Biol. 281, 227-39.

Rodriguez-Mari, A., Yan, Y., BreMiller, R., Wilson, C., Canestro, C., and Postlethwait, J. (2005) Characterization and expression pattern of zebrafish Anti-Mullerian hormone (amh) relative to sox9a, sox9b, and cyp19a during gonad development. Gene Expr. Patterns 5, 655-667.

Yan, Y. L., Willoughby, J., Liu, D., Crump, J. G., Wilson, C., Miller, C. T., Singer, A., Kimmel, C., Westerfield, M., and Postlethwait, J. H. (2005) A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Development 132, 1069-83.

Kuo, M., Postlethwait, J., Lee, W., Lour, S., Chan, W., and Chung, B. (2005) Gene duplication gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family. Biochem J. 389, 19-26.

Gloriam, D., Bjarnadottier, T., Yan, Y., Postlethwait, J., Schioth, H. B., and Fredriksson, R. (2005) The repertoire of trace amine G-protein coupled receptors: Large expansion in zebrafish. Mol. Phylogenet. Evol. 35, 470-82.

2004

Postlethwait, J. (2004) Evolution of the Zebrafish Genome. In "Fish Development and Genetics: the Zebrafish and Medaka Models" (Z. Gong and V. Korzh, Eds.), pp. 688. World Scientific Publishing Company.

Ruuskanen, J. O., Xhaard, H., Marjamaki, A., Salaneck, E., Salminen, T., Yan, Y. L., Postlethwait, J. H., Johnson, M. S., Larhammar, D., and Scheinin, M. (2004) Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. Mol. Biol. Evol. 21(1), 14-28.

Postlethwait, J., Amores, A., Cresko, W., Singer, A., and Yan, Y. L. (2004) Subfunction partitioning, the teleost radiation and the annotation of the human genome. Trends Genet. 20, 481-90.

Dodou, E., Barald, K. F. and Postlethwait, J. H. (2004) Ventralized zebrafish embryo rescue by overexpression of Zic2a. Zebrafish 1(3), 239-256.

Postlethwait, J., Ruotti, V., Carvan, M. J., and Tonellato, P. J. (2004) Automated analysis of conserved syntenies for the zebrafish genome. Methods Cell. Biol. 77, 255-71.

Papasani, M. R., Gensure, R. C., Yan, Y. L., Gunes, Y., Postlethwait, J. H., Ponugoti, B., John, M. R., Juppner, H., and Rubin, D. A. (2004) Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39. Endocrinology 145(11), 5294-304.

Naruse, K., Tanaka, M., Mita, K., Shima, A., Postlethwait, J., and Mitani, H. (2004) A medaka gene map: the trace of ancestral vertebrate proto-chromosomes revealed by comparative gene mapping. Genome Res. 14(5), 820-8.

McGuigan, K., Phillips, P. C., and Postlethwait, J. H. (2004) Evolution of sarcomeric myosin heavy chain genes: evidence from fish. Mol. Biol. Evol. 21,1042-56.

Fredriksson, R., Larson, E. T., Yan, Y. L., Postlethwait, J. H., and Larhammar, D. (2004) Novel neuropeptide Y Y2-like receptor subtype in zebrafish and frogs supports early vertebrate chromosome duplications. J. Mol. Evol. 58(1), 106-14.

Flores, M. V., Tsang, V. W., Hu, W., Kalev-Zylinska, M., Postlethwait, J., Crosier, P., Crosier, K., and Fisher, S. (2004) Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements. Gene Expr. Patterns 4, 573-81.

Cresko, W. A., Amores, A., Wilson, C., Murphy, J., Currey, M., Phillips, P., Bell, M. A., Kimmel, C. B., and Postlethwait, J. H. (2004) Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations. PNAS USA 101, 6050-5.

Cao, Y., Zhao, J., Sun, Z., Zhao, Z., Postlethwait, J., and Meng, A. (2004) fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos. Dev. Biol. 271, 130-43.

Amores, A., Suzuki, T., Yan, Y. L., Pomeroy, J., Singer, A., Amemiya, C., and Postlethwait, J. H. (2004) Developmental roles of pufferfish Hox clusters and genome evolution in ray-fin fish. Genome Res. 14, 1-10.

2003

Zhao, C. T., Shi, K. H., Su, Y., Liang, L. Y., Yan, Y., Postlethwait, J., and Meng, A. M. (2003) Two variants of zebrafish p100 are expressed during embryogenesis and regulated by Nodal signaling. FEBS Lett 543, 190-5.

Zhao, J., Cao, Y., Zhao, C., Postlethwait, J., and Meng, A. (2003) An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. Embo. J. 22, 6078-88.

Rhinn, M., Lun, K., Amores, A., Yan, Y. L., Postlethwait, J. H., and Brand, M. (2003) Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signaling. Mech. Dev. 120, 919-36.

Paw, B. H., Davidson, A. J., Zhou, Y., Li, R., Pratt, S. J., Lee, C., Trede, N. S., Brownlie, A., Donovan, A., Liao, E. C., Ziai, J. M., Drejer, A. H., Guo, W., Kim, C. H., Gwynn, B., Peters, L. L., Chernova, M. N., Alper, S. L., Zapata, A., Wickramasinghe, S. N., Lee, M. J., Lux, S. E., Fritz, A., Postlethwait, J. H., and Zon, L. I. (2003) Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat. Genet. 34, 59-64.

Nolte, C., Amores, A., Nagy Kovacs, E., Postlethwait, J., and Featherstone, M. (2003) The role of a retinoic acid response element in establishing the anterior neural expression border of Hoxd4 transgenes. Mech. Dev. 120, 325-35.

Masumoto, J., Zhou, W., Chen, F., Su, J., Kuwada, E., Hidaka, T., Katsuyama, J., Sagara, S., Taniguchi, P., Ngo-Hazelett, P., and Postlethwait, J. (2003) Caspy: A zebrafish caspase, activated by ASC oligomerization required for pharyngeal arch development. J. Biol. Chem. 278(6), 4268-4276.

Liu, D., Chu, H., Maves, L., Yan, Y. L., Morcos, P. A., Postlethwait, J. H., and Westerfield, M. (2003) Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification. Development 130, 2213-24.

Kalev-Zylinska, M. L., Horsfield, J. A., Flores, M. V., Postlethwait, J. H., Chau, J. Y., Cattin, P. M., Vitas, M. R., Crosier, P. S., and Crosier, K. E. (2003) Runx3 is required for hematopoietic development in zebrafish. Dev. Dyn. 228, 323-36.

Cresko, W. A., Yan, Y. L., Baltrus, D. A., Amores, A., Singer, A., Rodriguez-Mari, A., and Postlethwait, J. H. (2003) Genome duplication, subfunction partitioning, and lineage divergence: Sox9 in stickleback and zebrafish. Dev. Dyn. 228, 480-9.

Canestro, C., Bassham, S., and Postlethwait, J. H. (2003) Seeing chordate evolution through the Ciona genome sequence. Genome Biol. 4, 208.

2002

Postlethwait, J., Amores, A., Yan, Y., and Austin, C. A. (2002) Duplication of a portion of human chromosome 20q containing topoisomerase (top1) and snail genes provides evidence on genome expansion and the radiation of teleost fish. In "Aquatic Genomics" (N. Shimizu, T. Aoki, I. Hirono, and F. Takashima, Eds.) Springer, Tokyo.

Willot, V., Mathieu, J., Lu, Y., Schmid, B., Sidi, S., Yan, Y. L., Postlethwait, J. H., Mullins, M., Rosa, F., and Peyrieras, N. (2002) Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula. Dev. Biol. 241, 59-78.

Udovic, D., Morris, D., Dickeman, A., Postlethwait, J., and Wetherwax, P. (2002) Workshop Biology: Demonstrating the effectiveness of active learning in an introductory biology course. BioScience 272-281.

Ringholm, A., Fredriksson, R., Poliakova, N., Yan, Y. L., Postlethwait, J. H., Larhammar, D., and Schioth, H. B. (2002) One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology. J. Neurochem. 82, 6-18.

Rajarao, J. R., Canfield, V. A., Loppin, B., Thisse, B., Thisse, C., Yan, Y. L., Postlethwait, J. H., and Levenson, R. (2002) Two Na,K-ATPase beta 2 subunit isoforms are differentially expressed within the central nervous system and sensory organs during zebrafish embryogenesis. Dev. Dyn. 223, 254-61.

Pratt, S., Drejer, A. H., Foott, H., Barut, B., Brownlie, A., Postlethwait, J., Kato, Y., Yamamoto, M., and Zon, L. I. (2002) Isolation and characterization of zebrafish NFE2. Physiol. Gen. 91-98.

Kalev-Zylinska, M. L., Horsfield, J. A., Flores, M. V., Postlethwait, J. H., Vitas, M. R., Baas, A. M., Crosier, P. S., and Crosier, K. E. (2002) Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. Development 129, 2015-30.

Housworth, E. A., and Postlethwait, J. (2002) Measures of synteny conservation between species pairs. Genetics 162, 441-8.

Yan, Y. L., Yan, Y. L., Miller, C. T., Nissen, R. M., Singer, A., Liu, D., Kirn, A., Draper, B., Willoughby, J., Morcos, P. A., Amsterdam, A., Chung, B. C., Westerfield, M., Haffter, P., Hopkins, N., Kimmel, C., Postlethwait, J. H. (2002) A zebrafish sox9 gene required for cartilage morphogenesis. Development 129 (21), 5065-79.

Force, A., Amores, A., and Postlethwait, J. H. (2002) Hox cluster organization in the jawless vertebrate Petromyzon marinus. J. Exp. Zool. 294, 30-46.

Duner, T., Conlon, J. M., Kukkonen, J. P., Akerman, K. E., Yan, Y. L., Postlethwait, J. H., and Larhammar, D. (2002) Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor. Biochem. J. 364, 817-24.

Singer, A., H. Perlman, Y.-L. Yan, C. Walker, G. Corley-Smith, B. Brandhorst, and J.H. Postlethwait (2002) Sex-specific recombination rates in zebrafish (Danio rerio). Genetics 160, 649-657.

Canfield, V. A., Loppin, B., Thisse, B., Thisse, C., Postlethwait, J. H., Mohideen, M. A., Rajarao, S. J., and Levenson, R. (2002) Na,K-ATPase alpha and beta subunit genes exhibit unique expression patterns during zebrafish embryogenesis. Mech. Dev. 116, 51-9.

2001

Varga, Z. M., Amores, A., Lewis, K. E., Yan, Y. L., Postlethwait, J. H., Eisen, J. S., and Westerfield, M. (2001) Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development 128, 3497-509.

Topczewski, J., Sepich, D. S., Myers, D. C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J., and Solnica-Krezel, L. (2001) The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension. Dev. Cell 1, 251-64.

Rajarao, S. J., Canfield, V. A., Mohideen, M. A., Yan, Y. L., Postlethwait, J. H., Cheng, K. C., and Levenson, R. (2001) The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in the zebrafish, Danio rerio. Genome Res. 11, 1211-20.

Payne, T. L., Postlethwait, J. H., and Yelick, P. C. (2001) Functional characterization and genetic mapping of alk8. Mech. Dev. 100, 275-89.

Oates, A. C., Pratt, S. J., Vail, B., Yan, Y., Ho, R. K., Johnson, S. L., Postlethwait, J. H., and Zon, L. I. (2001) The zebrafish klf gene family. Blood 98, 1792-801.

Kalev, M. L., Horsfield, J. A., Flores, M. C., Postlethwait, J. H., Vitas, M. R., Baas, A. M., Crosier, P. S., and Crosier, K. E. (2001) Runt family transcription factors are required for zebrafish hematopoiesis, and heir function is disrupted by a human RUNX1-CBF2T transgene. Blood 98, 1892.

Henry, C. A., Crawford, B. D., Yan, Y. L., Postlethwait, J., Cooper, M. S., and Hille, M. B. (2001) Roles for zebrafish focal adhesion kinase in notochord and somite morphogenesis. Dev. Biol. 240, 474-87.

Crosier, P. S., Bardsley, A., Horsfield, J. A., Krassowska, A. K., Lavallie, E. R., Collins-Racie, L. A., Postlethwait, J. H., Yan, Y. L., McCoy, J. M., and Crosier, K. E. (2001) In situ hybridization screen in zebrafish for the selection of genes encoding secreted proteins. Dev. Dyn. 222, 637-44.

Chiang, E. F., Pai, C. I., Wyatt, M., Yan, Y. L., Postlethwait, J., and Chung, B. (2001) Two sox9 genes on duplicated zebrafish chromosomes: expression of similar transcription activators in distinct sites. Dev. Biol. 229, 149-163.

Chiang, E. F., Yan, Y. L., Guiguen, Y., Postlethwait, J., and Chung, B. (2001) Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain. Mol. Biol. Evol. 18, 542-50.

Chiang, E. F., Yan, Y. L., Tong, S. K., Hsiao, P. H., Guiguen, Y., Postlethwait, J., and Chung, B. C. (2001) Characterization of duplicated zebrafish cyp19 genes. J. Exp. Zool. 290, 709-14.

Bertrand, C., Chatonnet, A., Takke, C., Yan, Y. L., Postlethwait, J., Toutant, J. P., and Cousin, X. (2001) Zebrafish acetylcholinesterase is encoded by a single gene localized on linkage group 7. Gene structure and polymorphism; molecular forms and expression pattern during development. J. Biol. Chem. 276, 464-74.

Amemiya, C. T., Amores, A., Ota, T., Mueller, G., Garrity, D., Postlethwait, J. H., and Litman, G. W. (2001) Generation of a P1 artificial chromosome library of the Southern pufferfish. Gene 272, 283-9.

2000 and before

Woods, I. G., Kelly, P. D., Chu, F., Ngo-Hazelett, P., Yan, Y. L., Huang, H., Postlethwait, J. H., and Talbot, W. S. (2000) A comparative map of the zebrafish genome. Genome Res. 10, 1903-14.

Soderberg, C., Wraith, A., Ringvall, M., Yan, Y. L., Postlethwait, J. H., Brodin, L., and Larhammar, D. (2000) Zebrafish genes for neuropeptide Y and peptide YY reveal origin by chromosome duplication from an ancestral gene linked to the homeobox cluster. J. Neurochem. 75, 908-18.

Postlethwait, J. H., Woods, I. G., Ngo-Hazelett, P., Yan, Y. L., Kelly, P. D., Chu, F., Huang, H., Hill-Force, A., and Talbot, W. S. (2000) Zebrafish comparative genomics and the origins of vertebrate chromosomes. Genome Res. 10:1890-1902.

Liao, W., Ho, C. Y., Yan, Y. L., Postlethwait, J., and Stainier, D. Y. (2000) Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Development 127, 4303-13.

Kelly, P. D., Chu, F., Woods, I. G., Ngo-Hazelett, P., Cardozo, T., Huang, H., Kimm, F., Liao, L., Yan, Y. L., Zhou, Y., Johnson, S. L., Abagyan, R., Schier, A. F., Postlethwait, J. H., and Talbot, W. S. (2000) Genetic linkage mapping of zebrafish genes and ESTs. Genome Res. 10, 558-67.

de Martino, S., Yan, Y. L., Jowett, T., Postlethwait, J. H., Varga, Z. M., Ashworth, A., and Austin, C. A. (2000) Expression of sox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development. Dev. Dyn. 217, 279-92.

Brand, M., Lun, K., Reifers, F., Thisse, B., Thisse, C., Amores, A., Yan, Y. L., and Postlethwait, J. H. (2000) Subdivision of the early zebrafish neural primordium in response to posteriorizing signals. Eur. J. Neurosci. 12, 60.

Bassham, S., and Postlethwait, J. (2000) Brachyury (T) expression in embryos of a larvacean urochordate, Oikopleura dioica, and the ancestral role of T. Dev. Biol. 220, 322-32.

Starback, P., Lundell, I., Fredriksson, R., Berglund, M. M., Yan, Y. L., Wraith, A., Soderberg, C., Postlethwait, J. H., and Larhammar, D. (1999) Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish: the zYa receptor. Brain Res. Mol. Brain Res. 70, 242-52.

Postlethwait, J., Amores, A., Force, A., and Yan, Y. L. (1999) The zebrafish genome. Methods Cell Biol. 60, 149-63.

Postlethwait, J. H., Yan, Y. L., and Gates, M. A. (1999) Using random amplified polymorphic DNAs in zebrafish genomic analysis. Methods Cell Biol. 60, 165-79.

Oates, A. C., Wollberg, P., Pratt, S. J., Paw, B. H., Johnson, S. L., Ho, R. K., Postlethwait, J. H., Zon, L. I., and Wilks, A. F. (1999) Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line. Dev. Dyn. 215, 352-70.

Oates, A. C., Brownlie, A., Pratt, S. J., Irvine, D. V., Liao, E. C., Paw, B. H., Dorian, K. J., Johnson, S. L., Postlethwait, J. H., Zon, L. I., and Wilks, A. F. (1999) Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis. Blood 94, 2622-36.

O'Brien, S. J., Eisenberg, J. F., Miyamoto, M., Hedges, S. B., Kumar, S., Wilson, D. E., Menotti-Raymond, M., Murphy, W. J., Nash, W. G., Lyons, L. A., Menninger, J. C., Stanyon, R., Wienberg, J., Copeland, N. G., Jenkins, N. A., Gellin, J., Yerle, M., Andersson, L., Womack, J., Broad, T., Postlethwait, J., Serov, O., Bailey, E., James, M. R., Marshall Graves, J. A., and et al. (1999) Genome maps 10. Comparative genomics. Mammalian radiations. Wall chart. Science 286, 463-78.

Konig, C., Yan, Y. L., Postlethwait, J., Wendler, S., and Campos-Ortega, J. A. (1999) A recessive mutation leading to vertebral ankylosis in zebrafish is associated with amino acid alterations in the homologue of the human membrane-associated guanylate kinase DLG3. Mech. Dev. 86, 17-28.

Hukriede, N. A., Joly, L., Tsang, M., Miles, J., Tellis, P., Epstein, J. A., Barbazuk, W. B., Li, F. N., Paw, B., Postlethwait, J. H., Hudson, T. J., Zon, L. I., McPherson, J. D., Chevrette, M., Dawid, I. B., Johnson, S. L., and Ekker, M. (1999) Radiation hybrid mapping of the zebrafish genome. PNAS USA 96, 9745-50.

Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y. L., and Postlethwait, J. (1999) Preservation of duplicate genes by complementary, degenerative mutations. Genetics 151, 1531-45.

Delot, E., Kataoka, H., Goutel, C., Yan, Y. L., Postlethwait, J., Wittbrodt, J., and Rosa, F. M. (1999) The BMP-related protein radar: a maintenance factor for dorsal neuroectoderm cells? Mech. Dev. 85, 15-25.

Davidson, A. J., Postlethwait, J. H., Yan, Y. L., Beier, D. R., van Doren, C., Foernzler, D., Celeste, A. J., Crosier, K. E., and Crosier, P. S. (1999) Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily. Genome Res. 9, 121-129.

Corley-Smith, G. E., Brandhorst, B. P., Walker, C., and Postlethwait, J. H. (1999) Production of haploid and diploid androgenetic zebrafish (including methodology for delayed in vitro fertilization) Methods Cell Biol. 59, 45-60.

Amores, A., and Postlethwait, J. H. (1999) Banded chromosomes and the zebrafish karyotype. Methods Cell Biol. 60, 323-38.

Yan, Y. L., Talbot, W. S., Egan, E. S., and Postlethwait, J. H. (1998) Mutant rescue by BAC clone injection in zebrafish. Genomics 50, 287-9.

Yan, Y. L., Jowett, T., and Postlethwait, J. H. (1998) Ectopic expression of hoxb2 after retinoic acid treatment or mRNA injection: disruption of hindbrain and craniofacial morphogenesis in zebrafish embryos. Dev. Dyn. 213, 370-85.

Thompson, M. A., Ransom, D. G., Pratt, S. J., MacLennan, H., Kieran, M. W., Detrich, H. W., 3rd, Vail, B., Huber, T. L., Paw, B., Brownlie, A. J., Oates, A. C., Fritz, A., Gates, M. A., Amores, A., Bahary, N., Talbot, W. S., Her, H., Beier, D. R., Postlethwait, J. H., and Zon, L. I. (1998) The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev. Biol. 197, 248-69.

Talbot, W. S., Egan, E. S., Gates, M. A., Walker, C., Ullmann, B., Neuhauss, S. C., Kimmel, C. B., and Postlethwait, J. H. (1998) Genetic analysis of chromosomal rearrangements in the cyclops region of the zebrafish genome. Genetics 148, 373-80.

Risinger, C., Salaneck, E., Soderberg, C., Gates, M., Postlethwait, J. H., and Larhammar, D. (1998) Cloning of two loci for synapse protein Snap25 in zebrafish: comparison of paralogous linkage groups suggests loss of one locus in the mammalian lineage. J. Neurosci. Res. 54, 563-73.

Postlethwait, J. H., Yan, Y. L., Gates, M. A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E. S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T. S., Yelick, P., Beier, D., Joly, J. S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L. I., Johnson, S. L., and Talbot, W. S. (1998) Vertebrate genome evolution and the zebrafish gene map. Nat. Genet. 18, 345-9.

Liao, E. C., Paw, B. H., Oates, A. C., Pratt, S. J., Postlethwait, J. H., and Zon, L. I. (1998) SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes Dev. 12, 621-6.

Lee, K., H, Marden, J., Thompson, M., MacLennan, H., Kishimoto, Y., Pratt, S., Schulte-Merker, S., Hammerschmidt, M., Johnson, S., and Postlethwait, J. (1998) Cloning and genetic mapping of zebrafish BMP-2. Dev. Genet. 97-103.

Fornzler, D., Her, H., Knapik, E. W., Clark, M., Lehrach, H., Postlethwait, J. H., Zon, L. I., and Beier, D. R. (1998) Gene mapping in zebrafish using single-strand conformation polymorphism analysis. Genomics 51, 216-22.

Amores, A., Force, A., Yan, Y. L., Joly, L., Amemiya, C., Fritz, A., Ho, R. K., Langeland, J., Prince, V., Wang, Y. L., Westerfield, M., Ekker, M., and Postlethwait, J. H. (1998) Zebrafish hox clusters and vertebrate genome evolution. Science 282, 1711-4.

Schofield, R. M., Postlethwait, J. H., and Lefevre, H. W. (1997) MeV-ion microprobe analyses of whole Drosophila suggest that zinc and copper accumulation is regulated storage not deposit excretion. J. Exp. Biol. 200, 3235-43.

Postlethwait, J. H., and Talbot, W. S. (1997) Zebrafish genomics: from mutants to genes. Trends Genet. 13, 183-90.

Halpern, M. E., Hatta, K., Amacher, S. L., Talbot, W. S., Yan, Y. L., Thisse, B., Thisse, C., Postlethwait, J. H., and Kimmel, C. B. (1997) Genetic interactions in zebrafish midline development. Dev. Biol. 187, 154-70.

Bingulac-Popovic, J., Figueroa, F., Sato, A., Talbot, W. S., Johnson, S. L., Gates, M., Postlethwait, J. H., and Klein, J. (1997) Mapping of mhc class I and class II regions to different linkage groups in the zebrafish, Danio rerio. Immunogenetics 46, 129-34.

Johnson, S. L., Gates, M. A., Johnson, M., Talbot, W. S., Horne, S., Baik, K., Rude, S., Wong, J. R., and Postlethwait, J. H. (1996) Centromere-linkage analysis and consolidation of the zebrafish genetic map. Genetics 142, 1277-88.

Yan, Y. L., Hatta, K., Riggleman, B., and Postlethwait, J. H. (1995) Expression of a type II collagen gene in the zebrafish embryonic axis. Dev. Dyn. 203, 363-76.

Thisse, C., Thisse, B., and Postlethwait, J. H. (1995) Expression of snail2, a second member of the zebrafish snail family, in cephalic mesendoderm and presumptive neural crest of wild-type and spadetail mutant embryos. Dev. Biol. 172, 86-99.

Talbot, W. S., Trevarrow, B., Halpern, M. E., Melby, A. E., Farr, G., Postlethwait, J. H., Jowett, T., Kimmel, C. B., and Kimelman, D. (1995) A homeobox gene essential for zebrafish notochord development. Nature 378, 150-7.

Johnson, S. L., Africa, D., Horne, S., and Postlethwait, J. H. (1995) Half-tetrad analysis in zebrafish: mapping the ros mutation and the centromere of linkage group I. Genetics 139, 1727-35.

Halpern, M. E., Thisse, C., Ho, R. K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E. S., Postlethwait, J. H., and Kimmel, C. B. (1995) Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants. Development 121, 4257-64.

Thisse, C., Thisse, B., Halpern, M. E., and Postlethwait, J. H. (1994) Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Dev. Biol. 164, 420-9.

Postlethwait, J. H., Johnson, S. L., Midson, C. N., Talbot, W. S., Gates, M., Ballinger, E. W., Africa, D., Andrews, R., Carl, T., Eisen, J. S., and et al. (1994) A genetic linkage map for the zebrafish. Science 264, 699-703.

Johnson, S. L., Midson, C. N., Ballinger, E. W., and Postlethwait, J. H. (1994) Identification of RAPD primers that reveal extensive polymorphisms between laboratory strains of zebrafish. Genomics 19, 152-6.

Thisse, C., Thisse, B., Schilling, T. F., and Postlethwait, J. H. (1993) Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos. Development 119, 1203-15.

Yan, Y. L., and Postlethwait, J. H. (1990) Vitellogenesis in Drosophila: sequestration of a yolk polypeptide/invertase fusion protein into developing oocytes. Dev. Biol.140, 281-90.

Postlethwait, J., Saul, S., and Postlethwait, J. (1988) The antibacterial immune response of the Mediterranean fruit fly (Certatitis capitata). J. Insect Physiol. 34, 91-96.

Yan, Y. L., Kunert, C. J., and Postlethwait, J. H. (1987) Sequence homologies among the three yolk polypeptide (Yp) genes in Drosophila melanogaster. Nucleic Acids Res. 15, 67-85.

Postlethwait, J., Saul, S., Robertson, M., Grace, D., Abrams, K., and Brandenburg, E. (1987) Mechanisms of Immunity in Drosophila and Mediterranean Fruit Flies. In "Biotechnology in Crop Protein", Vol. ACS Symposium Series. ACS Publications.

Postlethwait, J., and Parker, J. (1987) Regulation of vitellogenesis in Drosophila. UCLA Symposia on Molecular and Cellular Biology. Molec. Biol. Invert. Devel. 29-42.

Postlethwait, J. (1987) Hormone and sex-specific gene regulation in Drosophila. Proceedings of the1st Congress of the Asia and Oceania Society for Comparative Endocrinology. 11-14.

Robertson, M., and Postlethwait, J. H. (1986) The humoral antibacterial response of Drosophila adults. Dev Comp Immunol 10, 167-79.

Postlethwait, J. H., and Kunert, C. J. (1986) Endocrine and genetic regulation of vitellogenesis in drosophila. Prog Clin Biol Res 205, 33-52.

Giorgi, F., Andolfi, P., Spinettie, I., Masetti, M., and Postlethwait, J. (1986) In Vivo uptake of haemolymph from a female sterile mutant into wild-type ovaries of Drosophila melanogaster. J. Insect Physiol 59-70.

Tamura, T., Kunert, C., and Postlethwait, J. (1985) Sex- and cell-specific regulation of yolk polypeptide genes introduced into Drosophila by P-element-mediated gene transfer. PNSA USA 82, 7000-4.

Postlethwait, J. H., and Giorgi, F. (1985) Vitellogenesis in insects. Dev Biol (N Y 1985) 1:85-126.

Minoo, P., and Postlethwait, J. (1985) Biosynthesis of Drosophila yolk polypeptides. Arch Insect Biochem and Physiol 7-27.

Minoo, P., and Postlethwait, J. H. (1985) Processing and secretion of a mutant yolk polypeptide in Drosophila. Biochem Genet 23, 913-32.

Johns, M. A., and Postlethwait, J. H. (1985) Naturally occurring quantitative variants of acid phosphatase-1 in Drosophila melanogaster. Biochem Genet 23, 465-82.

Giorgi, F., and Postlethwait, J. (1985) Yolk polypeptide secretion and vitelline membrane deposition in a female sterile Drosophila mutant. Devel Genet 133-150.

Giorgi, F., and Postlethwait, J. H. (1985) Development of gap junctions in normal and mutant ovaries of Drosophila melanogaster. J Morphol 185, 115-29.

Zhai, Q., Postlethwait, J., and Bodley, J. (1984) Vitellogenin synthesis in the lady beetle Coccinella septempunctata. Biochem and Physiol 7-27.

Shirk, P. D., Minoo, P., and Postlethwait, J. H. (1983) 20-Hydroxyecdysone stimulates the accumulation of translatable yolk polypeptide gene transcript in adult male Drosophila melanogaster. PNAS USA 80, 186-90.

Jowett, T., Postlethwait, J. H., and Roberts, D. B. (1982) Hormonal regulation of a larval haemolymph protein in Drosophila. Prog Clin Biol Res 85 Pt A, 373-380.

Postlethwait, J. H., and Jowett, T. (1981) Regulation of vitellogenesis in Drosophila. In "Scientific Papers of the Institute of Organic and Physical Chemistry of Wroclaw Technical University", Vol. No. 22, pp. 591-627.

Postlethwait, J., and Shirk, P. D. (1981) Genetic and endocrine regulation of vitellogenesis in Drosophila. Am Zool. 687-700.

Jowett, T., and Postlethwait, J. H. (1981) Hormonal regulation of synthesis of yolk proteins and a larval serum protein (LSP2) in Drosophila. Nature 292, 633-5.

Postlethwait, J. H. (1980) Genetic analysis of Drosophila vitellogenesis: a molecular weight variant of yolk polypeptide-2 in Drosophila simulans. Mol Gen Genet 178, 253-60.

Postlethwait, J. H., Lauge, G., and Handler, A. M. (1980) Yolk protein synthesis in ovariectomized and genetically agametic [X87] Drosophila melanogaster. Gen Comp Endocrinol 40, 385-90.

Postlethwait, J. H., and Jowett, T. (1980) Genetic analysis of the hormonally regulated yolk polypeptide genes in D. melanogaster. Cell 20, 671-8.

Postlethwait, J. H., Bownes, M., and Jowett, T. (1980) Sexual phenotype and vitellogenin synthesis in Drosophila melanogaster. Dev Biol 79, 379-87.

Jowett, T., and Postlethwait, J. H. (1980) The Regulation of yolk polypeptide synthesis in Drosophila ovaries and fat body by 20-hydroxyecdysone and a juvenile hormone analog. Dev Biol 80, 225-34.

Feigen, M. I., Johns, M. A., Postlethwait, J. H., and Sederoff, R. R. (1980) Purification and characterization of acid phosphatase-1 from Drosophila melanogaster. J Biol Chem 255, 10338-43.

Postlethwait, J. (1979) Postlethwait, J.H. (1979) Clonal analysis of Drosophila cuticular patterns. In Genetics and Biology of Drosophila, Vol. 2C, Ashburner and Wright, eds. Academic Press: London, pp. 359-442.

Postlethwait, J., and Handler, A. M. (1979) The roles of juvenile hormone and ecdysterone during vitellogenesis in isolated abdomens of Drosophila melanogaster. J Insect Physiol 455-460.

Postlethwait, J. (1978) Development of cuticular patterns in legs of a cell lethal mutant of Drosophila melanogaster. Whilhelm Roux Arch 37-57.

Postlethwait, J. H., and Jones, G. J. (1978) Endocrine control of larval fat body histolysis in normal and mutant Drosophila melanogaster. J Exp Zool 203, 207-14.

Postlethwait, J. H., and Handler, A. M. (1978) Nonvitellogenic female sterile mutants and the regulation of vitellogenesis in Drosophila melanogaster. Dev Biol 67, 202-13.

Postlethwait, J. H., and Kaschnitz, R. (1978) The synthesis of Drosophila melanogaster vitellogenins in vivo, in culture, and in a cell-free translation system. FEBS Lett 95, 247-51.

Handler, A. M., and Postlethwait, J. (1978) Regulation of vitellogenin synthesis in Drosophila by ecdysterone and juvenile hormone. J Exp Zool 247-254.

Handler, A. M., and Postlethwait, J. H. (1977) Endocrine control of vitellogenesis in Drosophila melanogaster: effects of the brain and corpus allatum. J Exp Zool 202, 389-402.

Postlethwait, J., Handler, A. M., and Gray, P. (1976) A genetic approach to the study of juvenile hormone control of vitellogenesis in Drosophila melanogaster. In The Juvenile Hormones (L. Gilbert, Ed.), pp. 449-469. Plenum Press, New York.

Postlethwait, J. (1975) Pattern formation in the wing and haltere imaginal discs after irradiation of Drosophila melanogaster first instar larvae. Whilhelm Roux Arch 29-50.

Postlethwait, J. H., and Gray, P. (1975) Regulation of acid phosphatase activity in the ovary of Drosophila melanogaster. Dev Biol 47, 196-205.

Postlethwait, J. H. (1974) Development of the temperature-sensitive homoeotic mutant ophthalmoptera of Drosophila melanogaster. Dev Biol 36, 212-7.

Postlethwait, J. H., and Girton, J. R. (1974) Development in genetic mosaics of aristapedia, a homoeotic mutant of Drosophila melanogaster. Genetics 76, 767-74.

Postlethwait, J. H. (1974) Juvenile hormone and the adult development of Drosophila. Biol Bull 147, 119-35.

Postlethwait, J. (1973) Molting of Drosophila first instar cuticle induced by a metamorphosing host. DIS 186-187.

Postlethwait, J. (1973) Effects of juvenile endocrine organs and juvenile hormone on the metamorphosis of Drosophila. DIS 174-176.

Postlethwait, J. (1973) A quantitative juvenile hormone assay on Drosophila. DIS 186-187.

Postlethwait, J. H., and Schneiderman, H. A. (1973) Developmental genetics of Drosophila imaginal discs. Annu Rev Genet 7, 381-433.

Postlethwait, J. H., and Schneiderman, H. A. (1973) Pattern formation in imaginal discs of Drosophila melanogaster after irradiation of embryos and young larvae. Dev Biol 32, 345-60.

Postlethwait, J. H., and Weiser, K. (1973) Vitellogenesis induced by juvenile hormone in the female sterile mutant apterous-four in Drosophila melanogaster. Nat New Biol 244, 284-5.

Guerra, M., Postlethwait, J. H., and Schneiderman, H. A. (1973) The development of the imaginal abdomen of Drosophila melanogaster. Dev Biol 32, 361-72.

Postlethwait, J. H., Bryant, P. J., and Schubiger, G. (1972) The homoeotic effect of "tumorous head" in Drosophila melanogaster. Dev Biol 29, 337-42.

Postlethwait, J. H., and Schneiderman, H. A. (1971) A clonal analysis of development in Drosophila melanogaster: morphogenesis, determination, and growth in the wild-type antenna. Dev Biol 24, 477-519.

Postlethwait, J. H., and Schneiderman, H. A. (1971) Pattern formation and determination in the antenna of the homoeotic mutant Antennapedia of Drosophila melanogaster. Dev Biol 25, 606-40.

Postlethwait, J. H., Poodry, C. A., and Schneiderman, H. A. (1971) Cellular dynamics of pattern duplication in imaginal discs of drosophila melanogaster. Dev Biol 26, 125-32.

Postlethwait, J. H., and Schneiderman, H. A. (1970) Induction of metamorphosis by ecdysone analogues. Drosophila imaginal discs cultured in vivo. Biol Bull 138, 47-55.

Postlethwait, J. H., and Schneiderman, H. A. (1969) A clonal analysis of determination in Antennapedia a homoeotic mutant of Drosophila melanogaster. PNAS USA 64, 176-83.

Some of our papers with high citation rates (ISI Web of Science).

Rodriguez et al., (2005) paper on amh is the 13th highest downloaded paper in the journal Gene Expression Patterns.

Force et al., (2002) paper on lamprey Hox clusters was the most frequently cited paper for the Journal of Experimental Zoology: Molecular and Developmental Evolution published in the year 2002.

Postlethwait et al., (2000) paper on zebrafish comparative genomics, cited: 165 times.

Woods et al., (2000) on zebrafish genetic map, cited: 147 times.

Force et al., (1999) on gene duplication, times cited: 606, ranks 14th of all time list for citations in the journal Genetics, only one more recent paper ahead of it, and ranking above milestones from Charlesworth, Luria & Delbruck, Sewall Wright, Allan Spradling, Lewontin, Nei, and so on.

Amores et al., (1998) on zebrafish Hox clusters, times cited: 490.

Postlethwait et al., (1994) zebrafish map, times cited 244.

Thisse et al., (1993) on zebrafish snail gene, times cited: 300

Books

Postlethwait, J., and Hopson, J. (2006) Modern Biology. Bolt, Rinehart and Winston, Orlando. (A biology textbook for high schools)

Postlethwait, J. and Hopson, J. (2005) Life! RCS Libri S.p.A-Milano. (Italian high school biology text)

Postlethwait, J., and Hopson, J. (2003) Explore Life. Brooks/Cole Thompson Learning.

Postlethwait, J. and Hopson, J. (2000) Corso di Biologia, McGraw-Hill editore, 2000 (In Italian).

Postlethwait, J. and Hopson, J. (1997) Corso di Biologia, McGraw-Hill Italia srl, piazza Emilia, 5, 20129 Milano.  (Italian high school biology text)

Postlethwait, J., Hopson, J., and Veres, R. (1993) Sciencza Della Vita, McGraw-Hill Italia srl, piazza Emilia, 5, 20129 Milano.  (Italian high school biology text)

Postlethwait, J., and Hopson, J. (1992, 1995) The Nature of Life. McGraw Hill, New York.

Postlethwait, J., Hopson, J., and Veres, R. (1992) Biologia, Per Le Scuole Medie Superiori, McGraw-Hill Italia srl, piazza Emilia, 5, 20129 Milano.  (Italian high school biology text).

Postlethwait, J., Hopson, J., and Veres, R. (1991) Biology! Bringing Science to Life. McGraw-Hill, New York.

Invited lectures, February 2000 to October 2008

2000 04 25 Venue: Michigan State University

Talk Title: Genome duplication and the origin of vertebrate genomes

Meeting Title: Animal Genomics Seminar Program

Invited by: Kim T. Scribner, Dept. of Fisheries and Wildlife, Michigan State University

2000 06 17 Venue: New Haven, CN, Society for Molecular Biology and Evolution

Talk title: Gene and genome duplications in the evolution of vertebrate development

Meeting title: Symposium on Molecular Evolution and Development

Invited by: Gunter P. Wagner, Yale University

2000 07 30 Venue: British Columbia

Talk title: Gene and genome duplications in vertebrate evolution

Invited seminar, Bamfield Marine Station

Invited by: Andy Spencer, Director, Bamfield Marine Station

2000 09 20 Venue: San Marcos, Texas

Talk title: Evolution of the zebrafish genome

Meeting title: Aquaria Fish Models of Human Disease

Invited by: Ronald B. Walter, Southwest Texas State University

2000 10 28 Venue: Heidelberg, Germany

Talk title: Mapping zebrafish expressed sequences and evolution of the zebrafish genome

Meeting title: Beyond the Identification of Transcribed Sequences: Functional and Expression Analysis,10th International Workshop

Invited by: Bernhard Korn, German Cancer Research Center, Heidelberg, Germany

2000 11 11 Venue: Tokyo University of Fisheries, Japan

Talk title: Zebrafish genomics: A comparative approach

Meeting title: International symposium on Aquatic Genomics, A Step toward the Great Future of Aquatic Genomics

Invited by: Professor Takashi Aoki, Tokyo University of Fisheries

2000 11 25 Venue: Ise, Japan

Talk title: Developmental genetic consequences of genome duplication in fish

Invited seminar: National Research Institute of Aquaculture

Invited by: Dr. Tohru Suzuki, NRIA, Ise, Japan

2001 04 26 Venue: Aussois, France

Talk title: Genome duplication and the evolution of gene function in development

Meeting title: Jaques Monod Conference: Gene and genome duplications and the evolution of novel gene functions

Invited by: Invited by Prof. Axel Meyer, University of Konstanz, Germany

2001 05 07 Venue: University of California, Davis

Talk title: Zebrafish and the evolution of vertebrate genomes

Meeting title: Seminars on Animal Genome Initiatives & Comparative Genomics

Invited by: Invited by Leslie A. Lyons, School of Veterinary Medicine, University of California, Davis

2001 06 18 Venue: Cambridge, Massachusetts, Whitehead Institute for Genome Research

Talk title: Duplication and evolution of fish HOX clusters

Meeting title: Hox Workshop

Invited by: Ken Dewar, Whitehead Institute for Genome Research

2001 07 05 Venue: Teipei, Taiwan, Institute of Molecular Biology, Academia Sinica

Talk title: Consequences of genome duplication for the control of development

Meeting title: mini-symposium on developmental biology

Invited by: James Che-Kun Shen, Institute of Molecular Biology, Academia Sinica

2001 07 08 Venue: Kyoto, Japan

Talk title: Duplicated genes, duplicated genomes, and the evolution of vertebrate development

Meeting title: 14th International Congress of Developmental Biology

Invited by: Masatoshi Takeichi, Department of Cell and Developmental Biology, RIKEN CDB, Kobe, Japan

2001 07 14 Venue: Sendai, Japan, Tohoku University

Talk title: Consequence of Genome Duplication for the Developmental Biology of Teleost

Meeting title: IDAC Summer Workshop on Developmental Biology

Invited by: Yuji Watanabe, Department of Molecular Neurobiology, Institute of Development, Aging & Cancer, Sendai, Japan

2001 09 10 Venue: Bloomington, Indiana

Talk title: Duplicated genes and the evolution of vertebrate development

Invited departmental seminar, Department of Biology, University of Indiana

Invited by: Jeffrey D. Palmer, Department of Biology, University of Indiana

2001 09 12 Venue: Bethesda, MD, NIH Campus

Talk title: Comparative genomics and fish models for ageing research

Meeting title: Comparative Biology of ageing workshop

Invited by: Jill Carrington, National Institute on Aging, NIH

2001 12 04 Venue: Milwaukee, WI, Medical College of Wisconsin

Talk title: Zebrafish genomics and the origin of the vertebrate genome

Invited departmental seminar, Medical College of Wisconsin

Invited by: Peter Tonellato

2001 12 05 Venue: Milwaukee, Wisconsin

Talk title: Evolution of gene function in duplicated genes

Invited departmental seminar, The Water Institute

Invited by: Dave Petering, NIEHS Center Director

2002 02 05 Venue: Howard University

Talk title: Jaws and sex determination: the evolution of functions in sox9 genes of zebrafish

Invited seminar, Department of Molecular Biology and Biochemistry

Invited by: Prof. Margaret Coombs, Howard University

2002 03 20 Venue: York, England, British Genetics Society

Talk title: Evolution of vertebrate genomes and morphological innovations

Meeting title: Genomes, evolution and development

Invited by: Peter Holland, Linacre Professor of Zoology, Department of Zoology, University of Oxford

2002 04 16 Venue: Ann Arbor, Michigan, University of Michigan

Talk title: Genome duplication and evolution

Meeting title: Short Course on Genome Evolution

Invited by: Joe Brzezinski, Ph.D. Candidate, Department of Human Genetics, University of Michigan

2002 04 16 Venue: Ann Arbor, Michigan, University of Michigan

Talk title: Evolution of duplicated genes and their roles in development

Seminar, Department of Human Genetics

Invited by: Reid Alisch, Department of Human Genetics

2002 04 17 Venue: Cold Spring Harbor, New York

Talk title: Gene and Genome Duplication and the Origin of Diversity

Meeting title: Symposium on Evolution of Developmental Diversity

Invited by: Nipam Patel, Department of Organismal Biology and Anatomy, University of Chicago

2002 05 07 Venue: Seattle, Washington, University of Washington

Talk title: Gene and Genome Duplication and the Origin of Diversity

Meeting title: Developmental Biology Training Grant Lecture

Invited by: Josette Ungos, graduate student

2002 05 07 Venue: Seattle, Washington, University of Washington, Department of Zoology

Talk title: Evolution of duplicated genes and their roles in development

Invited seminar

2002 11 01 Venue: Cincinatti, Ohio, National Association of Biology Teachers

Talk title: Case studies in non-majors biology courses

Meeting title: contributed workshop

2003 02 09 Venue: Waiheke Island, New Zealand

Talk title: Evolving roles of duplicated genes in Zebrafish development

Meeting title: New Zealand/Australia Zebrafish Meeting

Invited by: Philip S. Crosier, Department of Molecular Medicine & Pathology, The University of Auckland, New Zealand

2003 03 11 Walnut Creek, California, Department of Energy, Joint Genome Institute

Talk title: Oikopleura dioica: Eight Short DNA Molecules

Meeting title: Departmental seminar

Invited by: Jeffrey L. Boore, Head, Evolutionary Genomics Department, JGI, University of California, Berkeley

2003 05 28 Venue: Holmes Chapel, Cheshire, UK

Talk title: Genome Duplication and the Evolving Fish Genome

Meeting Title: Worldwide Genomic Resources for Alternative-Model Fish Species

Invited by Andrew Cossins, Laboratory for Environmental Gene Regulation, The University of Liverpool, UK

2003 05 30 Venue: Sean Connery Lecture Hall, Dundee, Scotland

Talk title: Zebrafish, a model for human development and disease

Meeting title: Departmental seminar

Invited by: Cheryll Tickle, Department of Cell and Developmental Biology, University of Dundee

2003 09 21 Venue: Nippon Convention Center, Chiba, Japan

Talk title: Why are there so many fish in the sea? Keynote speaker

Meeting title: Marine Biotechnology Conference 2003

Invited by: Russell Hill, University of Maryland

2003 09 26 Venue: National Olympic Memorial Youth Center Tokyo, Japan

Talk title: Genome duplication and the radiation of teleost fish

Meeting title: The 2nd International Symposium on Aquatic Genomics

Invited by: Takashi Aoki, Laboratory of Genetics and Biochemistry, Tokyo University of Fisheries

2003 09 28 Venue: American Type Culture Collection, Manassas, Virginia

Talk title: Genome Duplication in Teleost Fish Facilitates Analysis of Conserved Disease-related Gene Functions

Meeting title: Aquatic Animal Models of Human Disease

Invited by: Mike Schmale, Marine Biology and Fisheries, University of Miami, Florida

2003 11 20 Venue: University of Oklahoma, Norman, Oklahoma

Talk title: Genome Duplication in Teleost Fish Facilitates Analysis of Ancestral Disease-related Gene Functions

Departmental Seminar

Invited by: Bruce Roe, Department of Chemistry and Biochemistry, University of Oklahoma

2003 11 24 Venue: University of Oregon, Lewis Imaging Center

Talk title: Stickleback and the Genomics of Aggression

Meeting title: TATRIC Site Visit

Invited by: Michael Posner, Department of Psychology, University of Oregon

2004 01 29 Venue: University of South Florida

Talk title: Genome duplication facilitates analysis of gene function in zebrafish

Meeting title: Departmental seminar

Invited by: Jeffrey A. Yoder, Department of Biology, University of South Florida

2004 02 05 Venue: Oregon Health Sciences University, Portland, Oregon

Talk title: Genome Duplication in Teleost Fish Facilitates Analysis of Ancestral Disease-related Gene Functions

Meeting title: OHSU Translational Research Seminar

Invited by: Eric Orwoll, OHSU Bone and Mineral Research Unit

2004 03 03 Venue: Sanjo Conference Hall, University of Tokyo, Tokyo, Japan

Talk title: The consequences of genome duplication for the evolution of teleost fish

Meeting title: Todai International Symposium, Medaka Genome and Vertebrate Evolution

Invited by: Masaru Nonaka, Department of Biological Sciences, University of Tokyo, Tokyo, Japan

2004 03 12 Venue: Valley River Center, Eugene, Oregon

Talk title: Consequences of genome duplication for teleost evolution

Meeting title: IGERT Symposium on The Evolution of Gene Regulation

Invited by: Patrick Phillips, Center for Ecology and Evolutionary Biology, University of Oregon

2004 04 30 Venue: Stowers Institute for Medical Research, Kansas City, Missouri

Talk title: Connectivities of zebrafish and tetrapod genomes

Meeting title: The chicken genome, new tools and concepts

Invited by: Olivier Pourquié, Stowers Institute for Medical Research, Kansas City, Missouri

2004 05 01 Venue: University Park, Pennsylviania

Talk title: Why are there so many fish in the sea? The consequences of genome duplication for evolution and development of teleost fish

Meeting title: 2004 Penn State Genetics Symposium

Invited by: Keith C. Cheng, Department of Pathology, Biochemistry and Molecular Biology, Penn State University

2004 08 13 Venue: Mount Desert Island Biological Laboratory, Salisbury Cove, Maine

Talk title: Teleost genome duplication: A tool for analysis of gene function

Meeting title: Mount Desert Island Stem Cell Symposium

Invited by: Michael McKernan, Mount Desert Island Biological Laboratory

2004 08 17 Venue: Saudárkrókur, Iceland

Talk title: Genome duplication: a trait shared by teleost fish

Meeting title: Evolution, Ecology, and Ethology of Fishes

Invited by: Bjarni Jónsson, Institute of Freshwater Fisheries, University of Iceland

2004 09 01 Venue: Max-Planck-Institute of molecular Genetics, Berlin, Germany

Talk title: The Consequences of Genome Duplication for Evolution of Development

Meeting title: Departmental Seminar

Invited by: Heinz Himmelbauer, Max-Planck-Institute of Molecular Genetics, Berlin, Germany

2004 10 14: Hyatt Regency, Cambridge, Massachusetts

Talk title: A zebrafish model for Fanconi anemia

Meeting title: Fanconi Anemia Scientific Symposium

Invited by: Mary Ellen Eiler, Fanconi Anemia Research Foundation

2004 11 03 Venue: University of Tokyo, Japan

Talk title: Evolution and Developmental Roles of Duplicated Pufferfish Hox Clusters

Meeting title: Functional Genomics of Pufferfish

Invited by: Shugo Watabe, Aquatic Molecular Biology and Biotechnology, The University of Tokyo, Tokyo, Japan

2004 12 13 Venue: Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China

Talk title: 2004 12 13 The zebrafish genetic system

2004 12 14 Positional cloning in zebrafish

2004 12 16 Genome duplication, evolution, and development

2004 12 17 Zebrafish: A medical model

Meeting title: Graduate Genomics Course

Invited by: Anming Meng, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China

2005 01 13 Venue:, Tromsø, Norway

Talk title: Genome Duplication and the Origin of Biodiversity

Meeting title: Norwegian Biochemical Society annual winter meeting

Invited by: Inge W. Nilsen, Norwegian Institute of Fisheries & Aquaculture Research, Tromsø, Norway

2005 03 25 Venue: University of Miami, NSF/NIEHS Oceans & Human Health Center, Miami, Florida

Talk title: Genome duplication and the origin of fish diversity

Meeting title: Departmental Seminar

Invited by: Douglas Crawford, Center for Marine Genomics, University of Miami, Florida

2005 05 04 Venue: Oregon State University, Corvallis, Oregon

Talk title: Genome duplication and the radiation of teleost fish

Meeting title: Departmental Seminar

Invited by: James C. Carrington, Center for Gene Research and Biotechnology,

Oregon State University

2005 08 28 Venue: Cairns, Australia

Talk title: SoxE group genes in zebrafish development

Meeting title: Sox Meeting

Invited by: Peter Koopman, Institute for Molecular Bioscience, The University of Queensland, Australia

2005 09 03 Talk title: Evolution of the vertebrate brain and placodes: A view from the larvacean urochordate Oikopleura dioica

Meeting title: 15th International Society of Developmental Biologists Congress, Symposium on Evolution and Development

Invited by: Peter Currie, Laboratory Head, Developmental Biology Program,

University of New South Wales, Australia

2005 09 15 Venue: Mount Desert Island Marine Station, Maine

Talk title: Genome duplication and the evolution of zebrafish developmental mechanisms

Meeting title: 2005 Strategic Conference of Zebrafish Investigators

Invited by: Brant Weinstein, Unit on Vertebrate Organogenesis, Laboratory of Molecular Genetics, The National Institute of Child Health and Human Development

2005 09 22 Venue: Geneva, Switzerland

Talk title: The genomic conservation of the Fanconi Anemia network in the zebrafish Danio rerio

Meeting title: Fanconi Anemia Scientific Symposium

Invited by: Grover Bagby, Oregon Health Sciences University, Portland, Oregon

2005 10 29 Venue: Athens, Georgia

Talk title: Zebrafish models for Fanconi anemia, an inherited disease of genome instability

Meeting title: Aquatic Models for Human Disease

Invited by: Richard Winn, Aquatic Biotechnology and Environmental Laboratory, University of Georgia, Athens, Georgia

2005 12 02 Venue: Oregon Institute of Marine Biology, Charleston, Oregon

Talk title: The larvacean urochordate Oikopleura dioica and the evolutionary origins of vertebrate developmental innovations

Meeting title: Departmental Seminar

Invited by: Craig Young, Director, Oregon Institute of Marine Biology

2006 01 15 Venue: Orlando, Florida

Talk title: Zebrafish in Context: The consequences of genome duplication

Meeting title: Zebrafish in Context

Invited by: Jacqueline F. Webb, Department of Biology, Villanova University, Villanova, Pennsylvania

2006 04 27 Venue: Bethesda, Maryland

Talk title: A zebrafish model for Fanconi anemia

Meeting title: Squamous Cell Carcinoma in FA Patients Conference

Invited by: Grover Bagby, OHSU

2006 05 03 Venue: Hollings Marine Laboratory, Charleston, South Carolina

Talk title: Micrioarray-based mapping of naturally occurring genetic variants

Meeting title: Fundulus Genomics Strategy Workshop

Invited by: Karen G. Burnett, Hollings Marine Laboratory, Charleston, South Carolina

2006 05 19 Venue: University of Oregon

Talk title: The Origin of Animals with Backbones

Meeting title: Eugene Natural History Society

Invited by: Tom Titus, ENHS president

2006 07 30 Venue: University of Alaska, Anchorage

Talk title: Subfunction partitioning in the evolution of stickleback and other teleosts

Meeting title: Fifth International Conference on Stickleback Behavior and Evolution

Invited by: Contributed talk, not by invitation

2006 09 12 Venue: Friday Harbor Marine Laboratory, Washington

Talk title: More than one way to build a fish: Divergent partitioning of gene subfunctions in teleost lineages

Meeting title: Genomics and the Life Aquatic

Invited by: Katie Peichel, UW

2006 10 19 Venue: Bethesda, Maryland

Talk Title: Mutations in the Zebrafish Fanconi Anemia Gene Network

Meeting title: Eighteenth Annual International Fanconi Anemia Research Fund Scientific Symposium

Invited by: Grover Bagby, OHSU

2006 10 28 Venue: Sorrento, Italy

Talk title: More than one way to build a fish - more than one way to build a chordate

Meeting title: International Conference on Marine Genomics

Invited by: Giorgio Bernardi, Stazione Zoologica Anton Dohrn, Napoli, Italy

2007 02 02 Venue: Asilomar, California

Talk title: Zebrafish Models for Fanconi Anemia

Meeting title: 2nd Strategic Conference of Zebrafish Investigators

Invited by: Lila Solnica-Krezel

2007 02 12 Venue: Portland, Oregon

Talk title: A screen for FA therapeutics

Meeting title: Small Molecule Testing for Fanconi Anemia conference

Invited by: Grover Bagby, OHSU

Venue: Sanger Center, Hinxton, Great Britain

Talk title: Ohnologs gone missing: Nomenclature, annotation, and functional evolution of teleost genes

Meeting title: Second Fish Genome Meeting

Invited by: Hugues Roest Crollius, Laboratoire Dynamique et Organisation des Genomes, Paris, France

2007 04 24 Venue: Vancouver, British Columbia, Canada

Talk title: Genomics and Fish: Evolution of gene function in the Oikopleura, human, zebrafish, and salmonid genomes

Meeting title: Genome BC

Invited by: Ben F. Koop, University of Victoria, British Columbia, Canada

2007 05 17 Venue: Denali National Park, Alaska

Talk title: Zebrafish models for toxicological research

Meeting title: Denali retreat on perchlorate toxicity

Invited by: Frank Von Hippel, Univeristy of Alaska, Anchorage

Venue: Gif-sur-Yvette, France: at Equipe INRA U1126 "Morphogenèse du système nerveux des Chordés", UPR 2197 DEPSN, CNRS, Institut de Neurosciences A Fessard

Talk title: Stickleback and the evolution of developmental mechanisms

Meeting title: Departmental seminar

Invited by: Jean-Stéphane JOLY, GIF-SUR –YVETTE, FRANCE

2007 06 23 Venue: Villefranche-sur-Mer, Observatoire Océanologique

Talk title: The making of a urochordate without retinoic acid

Meeting title: 4th International Tunicate Meeting,

Contributed presentation

2007 07 16 Venue: University of Leicester, Great Britain

Talk title: Evolution of complexity across the vertebrate and teleost genome duplication events

Meeting title: ‘Symposium: The meaning and measurement of vertebrate complexity’ at the 8th International Congress of Vertebrate Morphologists

Invited by: Mark A. Purnell,

2007 10 11 Venue: Chicago, IL

Talk title: The Zebrafish Fanconi Anemia Network is Mechanistically Similar to Human

Meeting title: Fanconi Anemia Research Fund Scientific Symposium

Contributed oral presentation

2007 11 13 Venue: Multnomah Athletic Club, Portland, OR

Purpose: Acceptance speech

Meeting Title: Medical Research Foundation Discovery and Mentor Awards Reception

Invited by: John H. Fitchen, M.D.

2007 11 14 Venue: Molecular Probes, Eugene, OR

Purpose: Acceptance speech

Meeting Title: “Oregon Discovers: Miracles in the Making”

Invited by: The Pharmaceutical Research and Manufacturers of America

2008 01 12 Destination: San Diego, CA

Lecture: Consequences of genome duplication in teleost fish.

Meeting Title: Aquaculture Workshop, Plant and Animal Genomes Meeting

Invited by: Geoffrey C. Waldbieser

http://www.intl-pag.org/16/16-pag.html

2008 01 16 Venue: Western Oregon University

Seminar title: Fanconi Anemia: a zebrafish model for human disease

Meeting Title: Departmental Seminar

Invited by: Dr. Lonnie Guralnick

2008 01 31 Venue: Duke University and the Duke Comprehensive Cancer Center, Durham, NC

Lecture 1: Zebrafish Mutational Models for Fanconi Anemia

Lecture 2: What chordate lineages experienced genome duplications?

Meeting Title: Fourth Aquatic Animal Models of Human Disease Conference.

Invited by: Dr. David Hinton

2008 02 19 Venue: Oregon Health Sciences University, Department of Physiology & Pharmacology

Seminar title: The roles of microRNAs in cranioifacial patterning and skeletogenesis

Meeting Title: Departmental seminar.

Invited by: Dr. David Grandy

2008 02 19 Destination: UO

Purpose: L. Lokay presentation: Zebrafish models for human disease

Invited by: J. Flores, UO Development Office

2008 04 11 Venue: Syracuse University, New York

Seminar title: MicroRNAs and skeletal development.

Meeting Title: Department of Biology Seminar

Invited by: Dr. R. Craig Albertson

2008 04 14 Venue: Indiana University, Bloomington IN

Seminar Title: microRNAs in craniofacial patterning and skeletogenesis

Meeting Title: Biology Department Seminar

Invited by: Amanda Posto, graduate student

2008 04 25 Venue: Straub Hall, UO

Talk title: microRNAs, the evolution of behavior, and stickleback

Meeting Title: UO Evolutionary Psychology group

Invited by: Dr. John Orbel

2008 05 05 Destination: Salt Lake City, Utah

Lecture: Genome duplication and the evolution of developmental mechanisms

Meeting Title: Genetics Training Grant Annual Retreat

Invited by: Dr. David Grunwald

2008 05 20 Venue: National Institutes of Health, Bethesda, MD

Lecture: Zebrafish Models for Fanconi Anemia

Meeting Title: National Center for Resource Resources, NIH staff meeting

Invited by: Dr. M. Chang (NIH/NCRR)

2008 06 18 Venue: Palmer Station, Antarctica

Talk: Antarctic Icefish and osteoporosis

Meeting Title: Station seminar series.

Invited by: Dr. Bill Detrich

Other professional travel

2000 04 10: NSF, Arlington, Virginia

Purpose: IGERT PI meeting to discuss evaluating IGERT projects

Meeting title: IGERT Assessment Meeting

2000 04 28: Cold Spring Harbor Laboratory, New York

Purpose: Present posters on our zebrafish work

Meeting title: Annual Zebrafish Development and Genetics Meeting

2001 02 08: NSF, Arlington, Virginia

Purpose: Discussing Best Practices for IGERT Multidisciplinary Graduate Education and Training

Meeting title: IGERT 2001 PI Meeting

2001 06 11: Gaithersburg, Maryland

Purpose: Grant review panel

Meeting title: Comparative Medicine NIH study section

2001 10 11: Gaithersburg, Maryland

Purpose: Grant review panel

Meeting title: Comparative Medicine NIH study section

2001 10 16: Eugene, Oregon

Purpose: Presentation to Greg Mogel, the program officer for UO Department of Defense

Title: Zebrafish genomics and the development of the nervous system

Invited by: Paula Burkhart, University of Oregon

2001 10 31: Orlando Florida

Purpose: IGERT and UO minority recruitment

Meeting title: ABRCMS, Annual Biomedical Research Conference for Minority Students

2001 11 08: Montreal, Canada,

Purpose: Improve teaching skills

Meeting title: National Association of Biology Teachers,

Talk: Contributed workshop: Incorporating Real Life Studies into the Non-Majors Biology Course

2002 06 11: Gaithersburg, Maryland

Purpose: Grant review panel

Meeting title: Comparative Medicine NIH study section

2002 06 13: Madison, WI

Purpose: Present contributed posters on our research

Meeting title: Annual Zebrafish Development and Genetics Meeting

2002 09 06: Bloomington, Indiana

Purpose: Meet with IGERT CoPIs at Indiana University

Meeting title: Mini-symposium on the Microevolution of Development

2002 11 01: Cincinnati, Ohio

Purpose: Improve teaching skills

Meeting title: National Association of Biology Teachers

Talk: Contributed workshop on Active Learning in Biology

2003 02 03 Hilton Arlington Hotel, Arlington, Virginia

Purpose: NSF’s way to stimulate IGERT activities

Meeting title: 2003 IGERT PI meeting

2003 02 05 Gaithersberg, Maryland

Purpose: Grant review panel

Meeting title: Comparative Medicine NIH study section

2003 02 22 Eugene, Oregon, Lewis Center for Neuroimaging

Meeting title: Miniworkshop on MRI

Talk title: Using MRI to Investigate Evolution of Development and Behavior

Invited by Ray Nunnally, Director, Center for Neuroimaging, University of Oregon

2003 04 19 University of Oregon

Talk title: Genomics and the Evolution of Behavior

Meeting title: Brain Biology and Machine Initiative workshop

2003 04 24: Valley River Center, Eugene, Oregon

Talk title: Technology in Biology Education

Meeting title: Large Stores Group National Meeting, LSG Technology Forum

Invited by James Williams, University of Oregon

2003 11 24: University of Oregon, Lewis Imaging Center

Talk title: Stickleback and the Genomics of Aggression

Meeting title: TATRIC Site Visit

Invited by: Michael Posner, Department of Psychology, University of Oregon

2004 10 21: Austin, Texas

Purpose: Minority Recruiting for Department of Biology, University of Oregon

Meeting title: Science and Science Policy: Constructing an Inclusive Paradigm, Society for the Advancement of Chicanos and Native Americans in Science

2004 05 07: Adams Mark Hotel, St Louis, Missouri

Meeting title: Genetics Society of America, Board Meeting

2004 05 11 University of Oregon

Meeting title: Academic Excellence and Economic Development

Talk title: A zebrafish model for human disease

2004 06 10 Alaska

Purpose: Stickleback specimen collecting trip

2004 07 29 Madison, Wisconsin

Meeting title: Meeting on Zebrafish Development and Genetics

Contribution: Several posters

2004 10 21 Austin, Texas

Meeting title: Society for the Advancement of Chicanos and Native Americans in Science (SACNAS)

Purpose: Minority graduate student recruitment for IGERT and Biology Department

2004 11 12: Inn at the Market, Seattle, Washington

Meeting title: Genetics Society of America Advisory Board Meeting

Purpose: Help run the business of the GSA

2005 03 09: Watergate Hotel, Washington, D.C.

Meeting title: NIH Special Emphasis Panel/Scientific Review Group

Purpose: Review NIH grant proposals

2005 04 16: Holiday Inn, Tysons Corner, Virginia

Meeting title: NSF Developmental Systems Grant Proposal Review Panel

Purpose: Review NSF grant proposals

2005 05 16: Hyatt Regency, Washington, D.C.

Purpose: Meet with Ron Wyden, Gordon Smith, and Peter DeFazio to lobby for more funding for NIH and NSF

Meeting title: Capital Hill Day, Genetics Society of America Advisory Board

2005 05 18: Double Tree Hotel, Crystal City, Virginia

Purpose: NSF’s way of drumming up enthusiasm for IGERT

Meeting title: 2005 IGERT Project Meeting

2005 07 09 University of California, Santa Barbara, California

Purpose: Present our work on Oikopleura

Meeting title: International Urochordate Meeting

2006 01 08: Town and Country, San Diego, California

Purpose: Help direct Genetics Society of America

Meeting: Genetics Society of America Advisory Board Meeting

2006 01 19: Miami, Florida

Purpose: Advise COOH program

Meeting: External Advisory Committee, University of Miami, Center for Oceans and Human Health

2007 01 17: Miami, Florida

Purpose: Advise COOH program

Meeting: External Advisory Committee, University of Miami, Center for Oceans and Human Health

2007 10 31 Destination: Grambling University, Grambling, LA

Purpose: Presentation to NIH MARC site visit team as mentor of Grambling undergraduates, Dr. M. A. Himaya, Director.

Meeting Title: NIH MARC Site Visit

2008 01 06 Destination: Miami, Florida

Purpose: Advise COOH program

Meeting: External Advisory Committee, University of Miami, Center for Oceans and Human Health: Miami, FL

2008 01 20 Destination: University of Alaska, Anchorage

Purpose: External advisor

Meeting Title: Alaska INBRE advisor meeting

Invited by: Frank von Hippel, UAA

2008 02 27 Destination: Anchorage, AK

Purpose: Advise regarding NIH proposal

Meeting Title: INBRE Mentor Meeting

Invited by: Frank von Hippel

2008 05 24 to 2008 07 12 Destination: Palmer Station Antarctica

Purpose: NIH/NSF sponsored research on icefish

Invited by: Bill Detrich

Outreach talks:

2001 04 18: Eugene, Oregon, University of Oregon Retirees

Title: Zebrafish and the human genome

2001 10 16 Eugene, Oregon, Rotary Club

Title: Stem cells and zebrafish research at the University of Oregon

Invited by: Edward P. Thompson, Eugene

2002 10 11: University of Oregon

Purpose: Turn middle school students on to biology

Title: How can we learn what the genes actually do to cause a person’s body to develop, grow, and function in health and disease?

2002 03 15: Eugene, Oregon

Purpose: Talk to President and Deans, Hokkaido University, Japan, visitors to UO

Title: Zebrafish: A model for human development and disease

2005 04 07: University of Oregon

Purpose: To help turn on minority high school students to biology

Talk title: Zebrafish models for human disease

2006 02 03: University of Oregon

Purpose: To explain to university development office personnel the significance of zebrafish research

Talk Title: Zebrafish models for human disease

2006 03 08: Bethesda, Maryland

Purpose: Review NIH grants

Meeting: NIH Genome Research Review  (ID # 1701 211)

2007 04 20: University of Oregon

Purpose: To bring Institute of Neuroscience staff up to date on current research

Talk title: Fanconi Anemia and Sex Determination

2007 08 8 & 9 and 16: Science Factory, Eugene OR

Purpose: To turn kids on to science

Lessons: Why is a fish’s mouth shaped like it is?

2008 02 19 UO

Purpose: L. Lokay presentation: Zebrafish models for human disease

Invited by: J. Flores, UO Development Office

2008 04 17 Postlethwait Lab - Huestis Hall

Purpose: To turn kids on to science, 10 home-schooled middle schoolers

Lessons: Zebrafish models for Fanconi anemia

2008 10 17 Will 100, UO

Purpose: Natural History Society Meeting

Lessons: Antarctic Icefish, osteoporosis, and global warming

2009 01 - 08

Visiting Research Fellow

Biozentrum der Universitaet Wuerzburg, Wuerzburg, Germany

Research Support

Active Support

IOS-0719577 (Postlethwait, PI)	09/01/07-08/31/11
NSF
The Non-Vertebrate Chordate Oikopleura and Evolution of Vertebrate Developmental Innovations
Major Goals: The goals of this grant are to learn how vertebrates evolved from non-vertebrate chordates by cloning Oikopleura orthologs of neural crest-related genes, using in situ hybridization to learn their expression patterns, testing the developmental capacities of cells at Oikopleura's neural plate border, and by performing gain- and loss-of-function experiments with Oikopleura orthologs of key genes at each step of the neural crest hierarchy.

IOS-0719577 (Postlethwait, PI)	09/01/07-08/31/11
NSF
The Non-Vertebrate Chordate Oikopleura and Evolution of Vertebrate Developmental Innovations REU
Major Goals: Supplement to fund research experiences for undergraduates.

1 R01 AG031922 (Postlethwait, PI)	04/01/08-03/31/13
NIH
Developmental Mechanisms for the Evolution of Bone Loss
Major Goals: The goals of this grant are to identify genes and gene functions that have changed, under the force of natural selection, during the evolved loss of bone mineral density in certain lineages of Antartic fish, which mimics human diseases of low bone mineral density, including osteoporosis.

5 P01 HD22486 (Kimmel, PD; Postlethwait, co-PI)	04/01/07-06/30/12
NIH
Signaling Hierarchies in Vertebrate Development: CP3: Reciprocal Signaling in Skeletogenesis
Major Goals: Component project three investigates early developmental stages of zebrafish to understand reciprocal signaling in skeletogenesis. We hypothesize that a pathway patterning the palatal skeleton involves specific interactions among Sonic hedgehog, Platelet-derived growth factor, and other signals. We hypothesize that a pathway controlling histogenesis of cartilage and cartilage-replacement bone involves specific interactions among Bone morphogenetic proteins, Indian hedgehog, and Parathyroid hormone related protein.

R01 HG002995 (Moen, PI)	09/10/08-08/31/11
NIH sub-award with Fred Hutchinson Cancer Research Center
TILLING the Zebrafish Genome: A Reverse Genetics Approach
Major Goals: The goal of this grant is to identify mutations in 120 genes of interest to the members of the zebrafish research community and to make the available via submission to the Zebrafish International Resource Center.

Fanconi Anemia Research Fund, Inc. (Postlethwait, PI)	10/01/08-10/31/10
Screening for Therapeutics in Models of Fanconi Anemia
Major Goals: The goals of this grant are to produce and evaluate zebrafish models for Fanconi anemia and to use them to identify potential therapeutic molecules for FA patients by conducting a high-throughput small molecule screen for compounds that ameliorate the symptoms of the best zebrafish FA model.
RSG0918401DMC American Cancer Society (Zachery Wood, PI)		07/01/09 - 06/30/12
Sub-award University of Georgia
Structural and Biochemical Studies of Nucleotide Sugar Biosynthese in Vertebrates
To make transgenic animals by introducing mutations made in vitro into zebrafish embryos lacking enzyme activity. This will test the roles of specific residues for enzyme function in a living, developing vertebrate. We will examine these transgenic animals for rescue of the mutant phenotype, including examination of proteoglycan production and the collection of embryos for the examination of nucleotide-sugar pools. Following this, we will be able to treat fish with various drugs and help you to collect the metabolites for analysis.

1 R01 RR020833 (Postlethwait PI)	08/01/05-04/30/10
NIH
Resources for Teleost Gene Duplicates and Human Disease
The major goals of this project are: 1) To develop software resources to automate the identification and phylogenetic analysis of duplicated genes in the sequenced genomes of teleost fish; 2) To use the new software to identify, investigate, and make publicly accessible the set of gene duplicates that arose in the proposed ray-fin genome duplication event; 3) To identify the most recently diverging, pre-duplication ray-fin lineage, and make available tangible genomic resources; and 4) To create a resource of gene expression data for both copies of teleost duplicates of human disease genes. There is no overlap with "Tilling the Zebrafish Genome: A reverse genetics approach.”

1 R01 RR020833 (Postlethwait, PI)	09/01/09-08/31/11
NIH – Administrative Supplement (ARRA)
Resources for Teleost Gene Duplicates and Human Disease
Major Goals: This administrative supplement proposal requests funds to retain trained personnel and to purchase made-in-the-USA equipment to accelerate the parent grant's goal of making genomic resources for translational research available to the community.

NIH Sub-award: University of Colorado (David Cloutheir, PI) 1 U01 DE020076	09/1/09-08/31/14
Identification of MiRNAs involving midfacial development and clefting
Major Goals: The objective of this proposal is to identify miRNAs involved in normal midfacial development by taking a dual-species approach.

Completed Support (last 3 years)

5 R01 RR10715 (Postlethwait PI) 07/01/03-06/30/07

NIH, NCRR

Genomic Analysis in Zebrafish

The major goals of this project are: 1) To identify all duplicated genes from the Zebrafish sequencing project and note which ones are co-orthologs of human disease genes; 2) To conduct a genotype-driven screen to produce mutations in both Zebrafish copies of human disease genes deemed of high priority by the research community; and 3) To analyze mutations in genes involved in diseases of the neural crest and in neural patterning.

0345203 (Postlethwait PI) 07/01/03-06/30/07

NSF

The Non-Vertebrate Chordate Oikopleura and Evolution of Vertebrate Developmental Innovations.

The major goals of this project are: 1) To determine the fate map of Oikopleura embryos; 2) To test in Oikopleura, the developmental role of genes shown to be required for the development of vertebrate crest and placodes; and 3) To test in Oikopleura, the developmental role of orthologs of genes shown to be required for the development of the three-part vertebrate brain.

Fanconi Anemia Research Fund, Inc. (Postlethwait PI) 05/01/06-04/30/07

A Small Molecule Screen for Fanconi Anemia

The major goals of this project are: 1) Make zebrafish models of FA by a reverse genetic screen (TILLING) and by morpholino antisense oligonucleotides, and to use these models to investigate development of organs relevant to FA; 2) Use FA zebrafish to evaluate the incidence and histological types of neoplasia; and 3) Identify new players in the FA pathway in a phenotype-driven screen for mutants.

IBN 0236239 (Postlethwait PI) 01/10/03-01/09/07

NSF

Genetic Basis of Morphological Evolution in Stickleback

The major goals of this project are: 1) To identify quantitative trait loci (QTL) responsible for the phenotypic differences in dorsal spines, bony plates, and pelvic armamentation among three fresh water populations of Alaskan Stickleback; and 2) To clone, genetically map, and identify expression patterns of loci known to be involved in the construction of fins, spines, appendages, and dermal (intramembranous) bone.