Institute of Neuroscience Faculty
Associate Professor, Department of Biology
B.S., 1970, Canisius College
M.S., 1972, Maine, Orono
Ph.D., 1977, State University of New York, Albany
- Director, UO Summer Program for Undergraduate Research (SPUR)
- Director, NSF REU Site Program in Molecular Biosciences at the University of Oregon (UO-REU) ---NSF Research Experiences for Undergraduates
- Director, Alaska Oregon Research Training Alliance (AORTA) --- UO META Center for Systems Biology
- Coordinator, NIH R25 Summer Research Program National Institute of Child Health and Human Development (R25-SRP)
Cellular signaling; electrophysiological, biochemical, and mutational analysis of visual processing; phototransduction, adaptation, and ion transport; efferent modulation of cellular function.
Research in our laboratory is directed toward understanding communication and information flow in biological systems. The principal focus has been visual processing in the retina, including the physiology and chemistry of phototransduction and synaptic processing in the retina. The initial stages of visual processing take place within the photoreceptor cells in the retina. We investigate the mechanisms by which retinal cells achieve this information transfer and processing to generate proper visual function. Eyes of Drosophila and Zebrafish are used. Visual transduction and signal processing involve complex cascades of reactions, initiating several other simultaneous intracellular and membrane events that lead to the creation of an intricate electrical response that spreads to the synapse, sending information to higher order visual cells. We adopt a relatively broad experimental approach to examine these events, investigating not only intracellular chemistry but also membrane transport processes, electrical processes, and modulation of retinal function by input from higher CNS centers. Membrane biophysics, electrophysiology, pharmacology, microspectrophotometry, mathematical modeling, mutational analysis, and biochemistry are used. Use of these techniques in combination with genetic and molecular approaches offers a very promising strategy to reveal the orchestration of photoreceptor signaling the roles of specific proteins and protein subunits in physiological events. We collaborate with colleagues who use molecular and genetic techniques to study the Drosophila retina. We expect that this multifaceted approach will help elucidate fundamental processes, not only in vision, but in other cellular signaling systems as well.
- Ugarte G, Delgado R, O'Day PM, Farjah F, Cid LP, Vergara C, Bacigalupo J (2005) ClC-2 Chloride Channel Mediates Inward Rectification in Drosophila Retinal Photoreceptors. Journal of Membrane Biol. 207:151-160 .
Haab JE, O'Day PM (2004) Two preparations for recording ion channel activity in native rhabdomeral membranes of Drosophila retinal photoreceptor cells. Drosophila Information Service 2004
Ugarte G, O'Day PM, Bacigalupo J, Vergara C (2003) A CLC-2-like chloride conductance in Drosophila photoreceptors. Proceedings of the Physiological Society 541P
- Haab JE, Vergara C, Bacigalupo J, O'Day PM (2003) Two preparations for recording ion channel activity in native rhabdomeral membranes of Drosophila retinal photoreceptor cells. Drosophila Information Service 86: 161-164.
- O'Day PM (2002) Cellular and Molecular Neurobiology Hammond C. Quarterly Review of Biology 77:232-233.
- Haab JE, Vergara C, Bacigalupo J, O'Day PM (2000) Coordinated gating of TRP channels in native membranes from Drosophila retinas. J. Neurosci. 20(19):7193-7198.
- Haab JE, Vergara C, Bacigalupo J, O'Day PM (2000) Single channel recordings from native rhabdomeres of Drosophila photoreceptors. J. Physiol.523P:6P.
- Johnson EC, Gray-Keller MP, O'Day PM (1998) Rescue of excitation by inositol following Li(+)-induced block in Limulus ventral photoreceptors. Vis. Neurosci. 15:105-112.
- O'Day PM, Bacigalupo J, Vergara C, Ugarte G, Haab JE, (1997) Current issues in invertebrate phototransduction. Second messengers and ion conductances. Mol. Neurobiol..15:41-63.
- O'Day PM, Bacigalupo J, Vergara C, Ugarte G, Haab JE, (1997) Multiple pathways in invertebrate visual transduction. In: From Ion Channels to Cell-to-Cell Conversations; Latorre R, Sáez JC,eds. Plenum Publishing, Inc., pp 285-306.
- Bacigalupo J, O'Day PM(1996) The second messenger for visual excitation in invertebrate phototransduction. Biol. Res. 29:319-324.
- Bacigalupo J, Bautista DM, Brink DL, Hetzer JF, O'Day PM (1995) Cyclic-GMP enhances light-induced excitation and induces membrane current in Drosophila retinal photoreceptor. J. Neurosci. 15:7196-7200.
- Edwards SC, O'Day PM,Herrera DC (1995) Characterization of protein phosphateses type 1 and type 2A in Limulus nervous tissue: their light regulation in the lateral eye and evidence of involvement in the photoresponse. Vis. Neurosci.13:73-85.
- Johnson, E.C. and O'Day, P.M. (1995) Inhibitors of cyclic-GMP phosphodiesterase alter excitation of Limulus ventral photoreceptors in Ca(2+)-dependent fashion. J. Neurosci.15(10):6586-6591.
- Lee Y-H, Shah S,Suzuki E, Zars T, O'Day PM, Hyde DR (1994) The Drosophila dgqgene encodes a Ga protein that mediates phototransduction. Neuron 13:1143-1157.
- O'Day PM (1991) Na+/Ca2+-exchange in invertebrate photoreceptors. In Sodium-Calcium Exchange: proceedings of the second international conference. Ann. NY Acad. Sci. 639