Chabu, C., Doe, C.Q., (2008) Dap160/intersectin binds and activates aPKC to regulate cell polarity an cell cycle progression. Development 135, 2739-2746. | [PDF]
Siller, K.H., Doe, C.Q., (2008) Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts. Developmental Biology 319, 1-9. | [PDF]
Boone, J.Q., Doe, C.Q., (2008) Identification of Drosophila Type II Neuroblast Lineages Containing Transit Amplifying Ganglion Mother Cells. Developmental Neurobiology 69, 1185-1195. | [PDF]
Doe, C.Q., (2008) Neural stem cells: balancing self-renewal with differentiation. Development 135, 1575-1587. | [PDF]
Zhu, C.C., Boone, J.Q., Jensen, P.A., Hanna, S., Pdemski, L., Locke, J., Doe, C.Q., O'Connor, M., (2008) Drosopila Activin-ß and the Activin-like product Dawdle function redundantly to regulate proliferation in the larvel brain. Development 135, 513-521. | [PDF]
Atwood, S.X., Chabu, C., Penkert, R.R., Doe, C.Q., Prehoda, K.E., (2007) Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6-aPKC. Journal of Cell Science 120, 3200-3206. | [PDF]
Nipper, R.W., Siller, K.H., Smith, N.R., Doe, C.Q.. Prehods, K.E., (2007) G alpha i generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts. PNAS 104 (36), 14306-14311. | [PDF]
Cabernard, C., Doe, C.Q. (2007) Stem Cell Self-Renewal: Centrsomes on the Move. Current Biology 17: R465-R467. | [PDF]
Rolls, M.M., Satoh, D., Clyne, P.J., Henner, A.L., Uemura, T., Doe, CQ (2007) Polarity and intracellular compartmentalization of Drosophila neurons. Neural Development Apr 30;2(1):7 | [PDF]
Siegrist, S.E., Doe, C.Q. (2007) Microtubule-induced cortical cell polarity. Genes & Development Mar 1;21(5):483-96 | [PDF]
Egger, B.,Boone, J.Q., Stevens, N.R., Brand, A.H., Doe, C.Q. (2007) Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe. Neural Development Jan 5;2:1 | [PDF]
Lee, C-Y, Andersen, R.O., Cabernard, C., Manning, L., Tran, K.D., Lanskey, M.J., Bashirullah, A., Doe, C.Q. (2006) Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes & Development 20 (24), 3464-3474 | [PDF]
Doe, C.Q. (2006) Chinmo and neuroblast temporal identity. Cell Oct 20;127(2):254-6 | [PDF]
Grosskortenhaus, R., Robinson, K.J., Doe, C.Q. (2006) Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage. Genes & Development Sep 15;20(18):2618-27 | [PDF]
Siller, K.H., Cabernard, C., Doe, C.Q. (2006) The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts. Nature Cell Biology Jun;8(6):594-600 | [PDF]
Lee, C-Y., Wilkinson, B.D., Siegrist, S., Wharton, R., Doe, C.Q. (2006) Brat Is a Miranda Cargo Protein that Promotes Neuronal Differentiation and Inhibits Neuroblast Self-Renewal. Developmental Cell 10, 441-449 | [PDF]
Cleary M., Doe C.Q. (2006) Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window. Genes & Development 20:429-434 | [PDF]
Layden M.J., Odden J., Schmid A., Garces A., Thor S., Doe CQ, (2006) Zfh1, a somatic motor neuron transcription factor, regulates axon exit from the CNS. Developmental Biology 291:253-263 | [PDF]
Siegrist, S.E., Doe, C.Q. (2006) Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts. Development Feb 133(3):529-36 | [PDF]
Siegrist S., Doe C.Q. (2005) Microtubule-Induced Pins/Gai Cortical Polarity in Drosophila Neuroblasts. Cell 123:1323-1335 | [PDF]
Lee C-Y., Robinson K., Doe C.Q. (2006) Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature 439(2) 594-598 | [PDF]
Siller K., Serr M., Steward R., Hays T.S., Doe C.Q. (2005) Live Imaging of Drosophila Brain Neuroblasts Reveals a Role for Lis1/Dynactin in Spindle Assembly and Mitotic Checkpoint Control. Molecular Biology of the Cell 16;5127-5140 | [PDF]
Armstrong, J.A., Sperling, A.S., Deuring, R., Manning, L., Moseley, S.L., Papoulas, O., Piatek, C.I., Doe, C.Q., Tamkun, J.W. (2005) Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the delta-notch signal transduction pathway in Drosophila. Genetics Aug 170(4):1761-74 | [PDF]
Grosskortenhaus R, Pearson BJ, Marusich A, Doe C.Q. (2005) Regulation of temporal identity transitions in Drosophila neuroblasts. Developmental Cell. 2005 Feb;8(2):193-202 | [PDF]
Cheesman, S., Layden, M., von Ohlen, T., Doe, C.Q. and Eisen, J.S. (2004) Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation. Development 131 5221-5232. | [PDF]
Pearson, B., Doe, C.Q. (2004) Specification of temporal identity in the developing nervous system. Annual Review of Cell and Developmental Biology, Vol. 20, pages 619-647. | [PDF]
Albertson, R., Chabu, C., Sheehan, A. and Doe, C.Q. (2003) Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity. Journal of Cell Science 117, 6061-6070. | [PDF]
Karcavich, R. and Doe, C.Q. (2005) The Drosophila neuroblast 7-3 cell lineage: a model system for studying programmed cell death, Notch/Numb signaling, and sequential specification of GMC identity. The Journal of Comparative Neurology, 481:240-251 | [PDF]
Rolls, M.M. and and Doe, C.Q. Baz, Par-6 and aPKC are polarized in mature neurons, but are not required for in vivo axon specification in Drosophila. Nature Neuroscience., 421, 905-906. | [PDF]
Irion, U., Leptin, M., Siller, K., Fuerstenberg, S., Cai, Y., Doe, C.Q., Chia, W., and Yang, X. (2004) Abstrakt, a DEAD box protein, regulates inscuteable at a post-transcriptional level and is required for asymmetric division of neural and mesodermal progenitors. Current Biology, 14, 138-144. | [PDF]
Isshiki, T. and Doe, C.Q. (2004) Youthfulness of neural progenitors in Drosophila. Cell Cycle, 3, 296-299. | [PDF]
Pearson, B. and Doe, C.Q. (2003) Regulation of neuroblast competence in Drosophila. Nature, 425, 624-628 | [PDF] [Movie 1] [Movie 2]
Freeman, M., Delrow, J., Kim, J., Johnson, E., Doe, C.Q. (2003) Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function. Neuron, 38, 567-580 | [PDF] [Movie 1] [Movie 2]
McDonald, J.A. Fujioka, M., Odden, J.P., Jaynes, J.B., Doe, C.Q. (2003) Specification of motoneuron fate in Drosophila: Integration of positive and negative transcription factor inputs by a minimal eve enhancer. Journal of Neurobiology 57(2), 193-203 | [PDF]
Rolls, M.M. and Doe, C.Q. (2003) Cell Polarity: From embryo to axon. Nature 421, 905-906. | [PDF]
Albertson, R. and Doe, C.Q. (2003) Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nature Cell Biology 166-170. | [PDF] [Movie]
Ryter, J.M., Doe, C.Q., Matthews, B.M. (2002) Structure of the DNA Binding Region of Prospero Reveals a Novel Homeo-Prospero Domain. Structure10, 1541-1549. | [PDF]
Odden, J., Holbrook, S., and Doe, C.Q. (2002) Drosophila HB9 Is Expressed in a Subset of Motoneurons and Interneurons, Where It Regulates Gene Expression and Axon Pathfinding. The Journal of Neuroscience | [PDF]
Zelhof, A.C., Bao, H., Hardy, R.W., Zhang, B., and Doe, C.Q. Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in endocytosis., Development 128, 5005-5015. | [PDF]
Freeman, M. and Doe, C.Q. (2001) Asymmetric Prospero localization is required to generate mixed neuronal/glal lineages in the Drosophila CNS. Development128, 4103-4112. | [PDF]
Isshiki, T., Pearson, B., Holbrook, S., and Doe, C.Q. (2001) Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny. Cell106, 511-521. | [PDF]
Doe, C.Q. and B.B. Bowerman. (2001) Asymmetric cell division: fly neuroblast meets worm Zygote. Current Opinion Cell Biol, 13, 68-75. | [PDF]
Peng, C.-Y., L.M. Manning, R. Albertson and C.Q. Doe. (2000) The tumor suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblast.Nature408, 596-600. | [PDF]
Von Ohlen, T. and Doe, C.Q. (2000) Convergence of Dorsal, Dpp and Egfr
signaling pathways subdivides the Drosophila neuroectoderm into
three dorsoventral columns. Dev.
Biol.224, 362-372. | [PDF]
Schmid, A., Chiba, A., and Doe, C.Q. (1999) Clonal analysis of Drosophila embryonic
neuroblasts: neural cell types, axon projections and muscle targets. Development 126,
4653-4689. | [PDF] [Data]
Manning, L. and Doe, C.Q. (1999) Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage. Development 126, 2063-2071. | [PDF]
Weiss, J., Von Ohlen, T., Mellerick, D., Dressler, G., Doe, C., and Scott, M. (1998) Dorsal-ventral patterning in the Drosophila central nervous system: The intermediate neuroblasts defective homeobox gene specifies intermediate column identity. Genes & Dev. 12, 3591-3602. | [PDF]
McDonald, J.A., Holbrook, S., Isshiki, T., Weiss, J., Doe, C., and Mellerick, D. (1998) Dorsoventral patterning in the Drosophila CNS: the vnd homeobox gene specifies ventral column identity. Genes & Development. 12, 3603-3612. | [PDF]
Srinivasan, S., Peng, C.-Y., Skeath, J.B., Nair, S., Spana, E.P., Lassy, C., Doe, C.Q. (1998) Biochemical analysis of the Prospero protein during asymmetric cell division: cortical Prospero is highly phosphorylated relative to nuclear Prospero. Developmental Biology 204, 478-487. | [PDF]
Doe, C., Fuerstenberg, S. and Peng, C. (1998) Neural stem cells from fly to vertebrate. Journal of Neurobiology 36, 111-127. | [PDF]
Skeath, J.B., and Doe, C.Q. (1998) Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS. Development 125, 1857-1865. | [PDF]
Broadus, J.B., Fuerstenberg, S. and Doe, C.Q. (1998) Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter cell fate. Nature 391, 792-795. | [PDF]
Ikeshima-Kataoka, H., Skeath, J.B., Nabeshima, Y., Doe, C.Q., and Matsuzaki, F. (1997) Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions. Nature 390, 625-628. | [PDF]
Broadus, J.B. and Doe, C.Q. (1997) Extrinsic cues, intrinsic cues, and microfilaments regulate asymmetric localization of Prospero, Staufen, and Inscuteable in Drosophila neuroblasts. Current Biology. 7, 827-835. | [PDF]
McDonald, J.A. and Doe, C.Q. (1997) Establishing neuroblast-specific gene expression in the Drosophila CNS: huckebein is activated by wingless and hedgehog and repressed by engrailed and gooseberry. Development 124, 1079-1087. | [PDF]
Skeath, J.B. and Doe, C.Q. (1996) achaete-skute complex proneural genes contribute to neural precursor specification in the Drosophila CNS. Curr. Biol.,9, 1146-1152. | [PDF]
Spana, E.P. and Doe, C.Q. (1996) Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron 17, 21-26. | [PDF]
Chu-LaGraff, Q., Schmid, A., Leidel, J., Bronner, G., Jackle, H., and Doe, C.Q. (1995) huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding. Neuron 15, 1041-1051.
Spana, E., Kopczynski, C., Goodman, C.S. and Doe, C.Q. (1995) Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS. Development 121, 3489-3494. | [PDF]
Spana, E. and Doe, C.Q. (1995) The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. Development 121, 3187-3195. | [PDF]
Cui, X. and Doe, C.Q. (1995) The role of the cell cycle and cytokinesis in regulating gene expression in the Drosophila CNS. Development 121, 3233-3243. | [PDF]
Skeath, J.B., Zhang, Y., Holmgren, R., Carroll, S.B., and Doe, C.Q. (1995) Specification of neuroblast identity in the Drosophila embryonic central nervous system by gooseberry-distal. Nature 376, 427-430. | [PDF]
Broadus, J., Skeath, J.B., Spana, E.P., Bossing, T., Technau, G., Doe, C.Q. (1995) New neuroblast markers and the origin of the aCC/pCC neurons in the Drosophila central nervous system. Mechanisms of Development 53, 393-402 | [PDF]
Chu-LaGraff, Q., Doe, C.Q. (1993) Neuroblast Specification and Formation Regulated by wingless in the Drosophila CNS. Science 261, 1594-1597. | [PDF]